Mechanically sensitive, nonselective cation channels.

Mechanically sensitive, nonselective cation channels.
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机械敏感、非选择性阳离子通道。

DOI:
--
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发表时间:
1993
期刊:
EXS
影响因子:
--
通讯作者:
F. Sachs
F. Sachs
中科院分区:
--
文献类型:
--
作者:
X. C. Yang;F. Sachs

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机械敏感通道(MSCs)在植物和动物细胞中普遍存在。它们主要对膜张力作出反应,因此使它们成为来自渗透或水力梯度和剪切应力的力的良好换能器。它们也可以被膜电压和各种配体调节。MSCs最常见的是阳离子选择性,通过钙和单价离子,但有些是K+选择性的,少数是阴离子选择性的。间充质干细胞的密度约为0.2-5微克。间充质干细胞的普遍分布和生物物理特性使其成为各种细胞过程中理想的机械换能器。
Mechanically sensitive channels (MSCs) are ubiquitous in plant and animal cells. They respond primarily to membrane tension, thus making them good transducers for forces derived from osmotic or hydraulic gradients and shear stress. They may also be modulated by membrane voltage and various ligands. MSCs are most commonly cation selective, passing calcium as well as monovalent ions, but some are K+ selective, and a few are anion selective. MSCs occur at a density of about 0.2-5 per microns2. The universal distribution and biophysical properties of MSCs make them the ideal mechanotransducers in a wide variety of cellular processes.
DOI: 10.1152/ajpheart.1993.264.3.h960
发表时间: 1993-03
期刊: The American journal of physiology
影响因子: --
作者:
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通讯作者: A. Ruknudin;Frederick Sachs;J. Bustamante
DOI: 10.1097/00005344-199117002-00024
发表时间: 1991-01-01
影响因子: 3
作者:
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通讯作者: SACHS, F
DOI: 10.1016/0005-2736(86)90248-8
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影响因子: --
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通讯作者: K. W. Snowdowne
生物系统中的机械转导。
DOI: --
发表时间: 1988
影响因子: --
作者:
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通讯作者: Sachs,F
DOI: 10.1126/science.2646709
发表时间: 1989-02-24
期刊: SCIENCE
影响因子: 56.9
作者:
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通讯作者: AU, M