The oxygen-dissociation curve of blood, and as thermodynamical basis

The oxygen-dissociation curve of blood, and as thermodynamical basis
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DOI：
10.1098/rspb.1923.0006
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发表时间：
1923-02-01
期刊：
PROCEEDINGS OF THE ROYAL SOCIETY OF LONDON SERIES B-CONTAINING PAPERS OF A BIOLOGICAL CHARACTER
影响因子：
--
通讯作者：
Hill, AV
Hill, AV
中科院分区：
其他
文献类型：
--
作者：
Brown, WEL;Hill, AV

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Barcroft和Roberts（7）指出，在分压x下，通过仔细透析的血红蛋白溶液以可逆化合方式吸收的氧的体积由方程y/a= Kx/（1 + Kx）给出，式中a是高压下吸收的体积，K是常数。人们通常把a看作是统一，而把y看作是“饱和度”。如果假设反应体Hb和Hbo 2遵守普通渗透压定律，则可以从热力学角度推导出可逆化学反应Hb + O2 Hbo 2（II）的该方程。
It was shown by Barcroft and Roberts (7) that the volumeyof oxygen taken up in reversible combination, at partial pressurex, by carefully dialysed hæmoglobin solution, is given by the equationy/a= Kx/(1 + Kx), (I) whereais the volume taken up at a high pressure, and K is a constant. It is usual to takeaas unity, and to speak ofyas the “ degree of saturation.” This equation can be deduced thermodynamically for the reversible chemical reaction Hb + O2⇄ Hbo2(II) if we suppose the the reacting bodies Hb and Hbo2to obey the ordinary laws of osmotic pressure.