Deficits in past remembering extend to future imagining in a case of developmental amnesia
Deficits in past remembering extend to future imagining in a case of developmental amnesia
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DOI：
10.1016/j.neuropsychologia.2010.06.011
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发表时间：
2010-09-01
期刊：
影响因子：
2.6
通讯作者：
Rosenbaum, R. S.
中科院分区：
文献类型：
--
作者：
Kwan, D.;Carson, N.;Rosenbaum, R. S.
病人和神经影像学研究报告说，记忆过去个人经历的能力和想象未来个人经历的能力是相互关联的。情景记忆的丧失通常伴随着未来想象的丧失，而从事任何一种活动都会招募共同的大脑区域。情景记忆和未来想象之间的关系也表明了它们在个体发育中的共同出现。然而，尚不清楚一种能力在早期发育中出现的失败是否排除了另一种能力的发展。为了研究这种可能性，我们测试了H.C.，一名年轻女性，患有与双侧海马丢失相关的发育性遗忘症，并在使用Galton-Crovitz提示的自传体访谈的改编版本上进行人口统计学匹配的对照。在回应提示词时，参与者描述了过去的个人事件和想象的未来发生的个人事件，或可能发生的，在近和远的时间段。结果表明，在H.C.中，过去和未来事件产生的损伤模式是平行的，因此她对这两类事件的叙述都有类似的缺陷。这些结果表明，无论是在早年还是晚年获得的海马体健忘症，精神时间旅行都可能受到损害，这可能是由于早期发作的存储信息的细节重新组装和结合的缺陷。(C)2010爱思唯尔有限公司版权所有。
Patient and neuroimaging studies report that the ability to remember past personal experiences and the ability to envision future personal experiences are interconnected. Loss of episodic memory is typically accompanied by loss of future imagining, and engaging in either activity recruits common brain areas. The relationship between episodic memory and future imagining is also suggested by their co-emergence in ontogenetic development. However, it is unknown whether a failure of one ability to emerge in early development precludes the development of the other ability. To investigate this possibility, we tested H.C., a young woman with amnesia of developmental origin associated with bilateral hippocampal loss, and demographically matched controls on an adapted version of the Autobiographical Interview using Galton-Crovitz cueing. In response to cue words, participants described both past personal events and imagined future personal events that occurred, or could occur, in near and distant time periods. Results indicated a parallel pattern of impairment for both past and future event generation in H.C., such that her narratives of both types of events were similarly deficient. These results indicate that mental time travel can be compromised in hippocampal amnesia, whether acquired in early or later life, possibly as a result of a deficit in reassembling and binding together details of stored information from earlier episodes. (C) 2010 Elsevier Ltd. All rights reserved.