Impact of overweight and underweight on assisted reproduction treatment
Impact of overweight and underweight on assisted reproduction treatment
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DOI：
10.1093/humrep/deh485
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发表时间：
2004-11-01
影响因子：
6.1
通讯作者：
Tanbo, T
中科院分区：
文献类型：
--
作者：
Fedorcsák, P;Dale, PO;Tanbo, T
背景：体重过轻和超重可能影响生殖和干扰不孕症的治疗。本报告的目的是描述体重对IVF和ICSI治疗的独立影响。方法：对2660对夫妇的5019例IVF或ICSI治疗记录进行回顾性分析。在考虑了年龄和不孕症诊断的差异后，研究了体重指数（BMI）对治疗结果的影响。结果如下：BMI ≥ 30 kg/m2的肥胖妇女在3个治疗周期内的累积活产率为41.4% [95%可信区间（CI）32.1-50.7]，BMI 18.5-24.9 kg/m2的正常体重妇女为50.3（95% CI 47.0-53.7）。肥胖与孕6周前发生的早孕流产风险增加有关。BMI和促性腺激素的需求在刺激和BMI和收集的卵母细胞的数量之间的负相关性之间的正相关。体重不足（BMI
Background: Underweight and overweight may affect reproduction and interfere with treatment of infertility. The purpose of this report is to describe the independent effect of body weight on treatment with IVF and ICSI. Methods: Records of 5019 IVF or ICSI treatments in 2660 couples were reviewed. The influence of body mass index (BMI) on treatment outcome was examined, after accounting for differences in age and infertility diagnosis. Results: The cumulative live birth rate within three treatment cycles was 41.4% [95% confidence interval (CI) 32.1-50.7] in obese women with BMI greater than or equal to30 kg/m(2) and 50.3 (95% CI 47.0-53.7) in normal weight women with BMI 18.5-24.9 kg/m(2). Obesity was associated with an increased risk of early pregnancy loss occurring before 6 weeks gestation. Positive correlation between BMI and gonadotrophin requirement during stimulation and negative correlation between BMI and number of collected oocytes were observed. Underweight (BMI