Metabotropic glutamate receptor-dependent long-term potentiation
Metabotropic glutamate receptor-dependent long-term potentiation
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DOI：
10.1016/j.neuropharm.2009.01.002
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发表时间：
2009-03-01
影响因子：
4.7
通讯作者：
Anwyl, R.
中科院分区：
文献类型：
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作者：
Anwyl, R.
众所周知，LTP的最常见形式的诱导涉及N-甲基-D-天冬氨酸受体的激活。然而，大量的证据也表明，在兴奋性突触上的主细胞和中间神经元上的某些形式的LTP诱导依赖于代谢型谷氨酸受体（mGluRs）的激活。mCluR依赖性UP发生在大脑的广泛区域，包括新皮质、海马、纹状体和丘脑核。已经发现UP的mGluR依赖形式是多样的，涉及mGluR 1或mGluR 5的激活，并且可以是AMPAR介导的传递或WDAR介导的传递。此外，mGluR依赖性UP可能涉及其他受体的激活，特别是NMDAR、多巴胺和腺苷受体的激活。mGluR依赖性UP可以在突触前或突触后表达，并且可以涉及一系列细胞内介质，包括蛋白激酶C（PKC）和蛋白激酶A（PKA）、酪氨酸激酶Src和一氧化氮（NO）。(C)2009年由Elsevier Ltd.出版
The induction of the most common form of LTP is well known to involve activation of N-methyl-D-aspartate receptors. However, considerable evidence has also shown that certain forms of LTP induction at excitatory synapses onto both principle cells and interneurons are dependent on activation of metabotropic glutamate receptors (mGluRs). mCluR-dependent UP occurs in widespread areas of the brain including the neocortex, hippocampus, striatum and nucleus accumbens. mGluR-dependent forms of UP have been found to be diverse, involving activation of mGluR1 or mGluR5 and can be of AMPAR-mediated transmission or of WDAR-mediated transmission. Furthermore, the mGluR-dependent UP may involve activation of other receptors, in particular, activation of NMDAR, dopamine and adenosine receptors. mGluR-dependent UP can be expressed presynaptically or postsynaptically, and can involve a range of intracellular mediators including protein kinase C (PKC) and protein kinase A (PKA), tyrosine kinase Src and nitric oxide (NO). (C) 2009 Published by Elsevier Ltd.