Muscle strength and gait speed rather than lean mass are better indicators for poor cognitive function in older men
Muscle strength and gait speed rather than lean mass are better indicators for poor cognitive function in older men
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DOI：
10.1038/s41598-020-67251-8
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发表时间：
2020-06-25
影响因子：
4.6
通讯作者：
Pasco, Julie A.
中科院分区：
文献类型：
--
作者：
Sui, Sophia X.;Holloway-Kew, Kara L.;Pasco, Julie A.
我们的目的是检查老年男性的肌肉力量、功能和质量与认知的关系。该横截面数据集包括 292 名 60 岁以上的男性。通过测力法测量握力（kg），通过4米步行速度（m/s）测量步态速度（m/s），通过双能X射线吸收测量法测量四肢瘦质量（kg）。认知评估涵盖四个领域：精神运动功能、注意力、视觉学习和工作记忆。计算整体认知的综合分数。双变量分析表明，握力和步态速度与认知功能呈正相关。考虑到混杂因素后，握力和精神运动功能、步态速度和精神运动功能、步态速度和注意力、握力和整体认知、步态速度和整体认知方面，个体肌肉（或身体）测量和认知表现之间保持正相关。在多变量模型中，握力和步态速度独立预测精神运动功能和整体认知。调整混杂因素后，没有发现瘦体重和认知之间存在关联。因此，低肌肉力量和较慢的步态速度，而不是低瘦体重，与老年男性认知能力差有关。
We aimed to examine muscle strength, function and mass in relation to cognition in older men. This cross-sectional data-set included 292 men aged >= 60yr. Handgrip strength (kg) was measured by dynamometry, gait speed by 4-metre walk (m/s) and appendicular lean mass (kg) by dual-energy x-ray absorptiometry. Cognition was assessed across four domains: psychomotor function, attention, visual learning and working memory. Composite scores for overall cognition were calculated. Bivariate analyses indicated that handgrip strength and gait speed were positively associated with cognitive function. After accounting for confounders, positive associations between individual muscle (or physical) measures and cognitive performance were sustained for handgrip strength and psychomotor function, gait speed and psychomotor function, gait speed and attention, handgrip strength and overall cognition, and gait speed and overall cognition. In multivariable models, handgrip strength and gait speed independently predicted psychomotor function and overall cognition. No associations were detected between lean mass and cognition after adjusting for confounders. Thus, low muscle strength and slower gait speed, rather than low lean mass, were associated with poor cognition in older men.