Spontaneous behaviors drive multidimensional, brainwide activity
Spontaneous behaviors drive multidimensional, brainwide activity
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DOI：
10.1126/science.aav7893
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发表时间：
2019-04-19
期刊：
影响因子：
56.9
通讯作者：
Harris, Kenneth D.
中科院分区：
文献类型：
--
作者：
Stringer, Carsen;Pachitariu, Marius;Harris, Kenneth D.
感觉皮层中的神经元群体对感觉刺激产生可变的反应，并且即使没有外部感觉输入也表现出复杂的自发活动。皮质变异性和自发活动已经被不同地提出来表示随机噪声、先前经验的回忆或正在进行的行为和认知变量的编码。记录了小鼠视觉皮层中超过10，000个神经元，我们观察到自发活动可靠地编码了一种高维潜伏状态，这种状态部分与小鼠正在进行的行为有关，不仅在视觉皮层中表现出来，而且在前脑中也表现出来。感官输入并没有中断这个正在进行的信号，而是在正交维度上添加了外部刺激的表示。因此，视觉皮层群体活动，尽管其明显的嘈杂结构，可靠地编码的感官和多维行为信息的正交融合。
Neuronal populations in sensory cortex produce variable responses to sensory stimuli and exhibit intricate spontaneous activity even without external sensory input. Cortical variability and spontaneous activity have been variously proposed to represent random noise, recall of prior experience, or encoding of ongoing behavioral and cognitive variables. Recording more than 10,000 neurons in mouse visual cortex, we observed that spontaneous activity reliably encoded a high-dimensional latent state, which was partially related to the mouse's ongoing behavior and was represented not just in visual cortex but also across the forebrain. Sensory inputs did not interrupt this ongoing signal but added onto it a representation of external stimuli in orthogonal dimensions. Thus, visual cortical population activity, despite its apparently noisy structure, reliably encodes an orthogonal fusion of sensory and multidimensional behavioral information.