Rat behavior and dopamine release are modulated by conspecific distress.
Rat behavior and dopamine release are modulated by conspecific distress.
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DOI：
10.7554/elife.38090
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发表时间：
2018-11-28
期刊：
影响因子：
7.7
通讯作者：
Roesch MR
中科院分区：
文献类型：
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作者：
Lichtenberg NT;Lee B;Kashtelyan V;Chappa BS;Girma HT;Green EA;Kantor S;Lagowala DA;Myers MA;Potemri D;Pecukonis MG;Tesfay RT;Walters MS;Zhao AC;Blair RJR;Cheer JF;Roesch MR
老鼠表现出“移情”，使它们成为理解这种行为的神经基础的模型。我们显示的数据与这些发现一致，但也表明行为和多巴胺（DA）的释放反映了对发生在另一个人身上的食欲和厌恶事件的主观而非客观评价。我们记录DA释放在两个范例：一个涉及线索预测不可避免的休克同种和另一个允许大鼠避免奖励时，有有害的后果同种。行为和DA反映亲社会的相互作用，DA抑制减少线索，预测休克的存在下的同种和DA释放观察到的自我回避试验时，同种幸免。然而，DA也增加时，同种受到冲击，而不是记录大鼠和DA释放在同种回避试验低于当大鼠避免休克为自己。
Rats exhibit ‘empathy’ making them a model to understand the neural underpinnings of such behavior. We show data consistent with these findings, but also that behavior and dopamine (DA) release reflects subjective rather than objective evaluation of appetitive and aversive events that occur to another. We recorded DA release in two paradigms: one that involved cues predictive of unavoidable shock to the conspecific and another that allowed the rat to refrain from reward when there were harmful consequences to the conspecific. Behavior and DA reflected pro-social interactions in that DA suppression was reduced during cues that predicted shock in the presence of the conspecific and that DA release observed on self-avoidance trials was present when the conspecific was spared. However, DA also increased when the conspecific was shocked instead of the recording rat and DA release during conspecific avoidance trials was lower than when the rat avoided shock for itself.