Imaging Appetite-Regulating Pathways in the Central Nervous System Using Manganese-Enhanced Magnetic Resonance Imaging
Imaging Appetite-Regulating Pathways in the Central Nervous System Using Manganese-Enhanced Magnetic Resonance Imaging
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DOI：
10.1159/000163751
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发表时间：
2009-01-01
影响因子：
4.1
通讯作者：
Bell, Jimmy D.
中科院分区：
文献类型：
--
作者：
Parkinson, James R. C.;Chaudhri, Owais B.;Bell, Jimmy D.
全球肥胖人数的增加促使人们加倍努力，以了解能量稳态的控制。深入了解控制食欲调节的机制对于理解肥胖的病理生理学和设计有效的治疗干预措施至关重要。利用肠道分泌的激素饱腹感信号需要更深入地了解它们与中枢神经系统（CNS）食欲控制回路的相互作用。锰增强磁共振成像是一种新技术，最近被用于研究肠肽对中枢神经系统食欲回路的影响。利用锰离子积累作为神经元活动的标志，下丘脑内关键食欲中心的信号强度在外周注射肠道激素后发生了变化。与目前用于研究肠道激素与中枢神经系统相互作用的方法相比，锰增强磁共振成像具有几个优势，并且在食欲调节以外的领域具有应用潜力。版权所有(c) 2008 S. Karger AG，巴塞尔
The global increase in obesity has led to a redoubling of efforts directed at understanding the control of energy homeostasis. Insight into the mechanisms which govern appetite regulation is central to understanding the pathophysiology of obesity and the design of effective therapeutic interventions. Exploitation of hormonal satiety signals secreted by the gut requires greater insight into their interaction with central nervous system (CNS) circuits of appetite control. Manganese-enhanced magnetic resonance imaging is a novel technique, recently adapted to investigate the effects of gut peptides on CNS appetite circuits. Using manganese ion accumulation as a marker of neuronal activity, changes in signal intensity in key appetite centres within the hypothalamus following peripheral injection of gut hormones have been demonstrated. Manganese-enhanced magnetic resonance imaging offers several advantages over methodologies currently used for the study of gut hormone interactions with the CNS and has the potential for application in fields beyond appetite regulation. Copyright (c) 2008 S. Karger AG, Basel