The effects of the extract mixture of alfalfa and perilla on lowering serum lipid, protecting liver and aortic wall in rats
The effects of the extract mixture of alfalfa and perilla on lowering serum lipid, protecting liver and aortic wall in rats
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发表时间：
2005
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通讯作者：
W. Ye;Chen Qing-min;Cao Wei-xin;Hu Xue-hua;Jiang Yong-mei
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作者：
W. Ye;Chen Qing-min;Cao Wei-xin;Hu Xue-hua;Jiang Yong-mei
目的：研究苜蓿紫苏提取物混合物对大鼠的降血脂、保护肝脏和主动脉壁的作用。方法：60只SD大鼠随机分为6组，分别饲喂不同的饲料。分别于给药后7 d和14 d处死大鼠，测定血脂、肝脏和主动脉壁胆固醇含量及组织病理学改变。结果：高脂喂养大鼠血清TC、LDL-C、肝脏及主动脉壁胆固醇含量明显升高。光镜下高脂组大鼠肝脏内可见脂滴和胆固醇结晶。与高脂组相比，苜蓿紫苏组大鼠血清和组织中的这些指标均显著降低。结论：苜蓿紫苏提取物混合物可预防高脂喂养大鼠血清TC、LDL-C、肝脏和主动脉壁胆固醇含量的升高，并可预防肝脏脂肪浸润和胆固醇存款。
Objectives: To investigate the effects of the extract mixture of alfalfa and perilla on lowering serum lipid, protecting liver and aortic wall in rats. Methods: Sixty SD rats were divided into six groups and were fed different diet. After seven or fourteen days, the rats were put to death and measured for serum lipids, cholesterol content of liver and aortic wall, and pathological change of the tissue. Results: There was a significant increase of serum TC, LDL-C, cholesterol content of liver and aortic wall in the high-fat fed rats. Under light microscope, there were lipid droplets and cholesterol crystal in liver of group high-fat. Compared with the group high-fat, the rats had a significant decrease of those measurements in serum or in tissue in the alfalfa and perilla group. Conclusions: The extract mixture of alfalfa and perilla could prevent the increase of serum TC, LDL-C, cholesterol content of liver and aortic wall in high-fat fed rats, and also prevent the fatty infiltration and cholesterol deposit of liver.