Neuropsychologic effects of long-term exposure to pesticides: Results from the French Phytoner study
Neuropsychologic effects of long-term exposure to pesticides: Results from the French Phytoner study
复制标题
DOI：
10.2307/3454828
复制
发表时间：
2001-08-01
影响因子：
10.4
通讯作者：
Brochard, P
中科院分区：
文献类型：
--
作者：
Baldi, I;Filleul, L;Brochard, P
Phytoner研究调查了波尔多葡萄园工人的神经心理表现与长期接触杀虫剂之间的可能联系，他们大多数使用杀菌剂。在1997年2月至1998年8月的917名调查对象中，528人通过混合和/或喷洒农药直接暴露（平均暴露时间22年），173人通过接触处理过的植物间接暴露，216人从未暴露过农药。所有受试者都在家中接受了由训练有素的心理学家进行的神经心理学测试。暴露在测试中的受试者，在测试中得分较低的风险不断增加。当考虑到教育水平、年龄、性别、饮酒、吸烟、环境暴露和抑郁症状，并将分析限制在亚组时，大多数测试的结果仍然显著，优势比（OR）超过2。这些结果指出了在职业条件下低水平接触农药的长期认知影响。鉴于农药使用的频率和认知障碍可能造成的残疾，需要进一步的毒理学和流行病学研究来证实这些结果并评估对公众健康的影响。
The Phytoner study investigated a possible association between neuropsychologic performances and long-term exposure to pesticides in Bordeaux vineyard workers, most of whom use fungicides. Among the 917 subjects interviewed from February 1997 to August 1998, 528 were directly exposed to pesticides through mixing and/or spraying (mean exposure duration: 22 years), 173 were indirectly exposed through contact with treated plants, and 216 were never exposed. All subjects performed neuropsychologic tests administered at home by trained psychologists. The risk of scoring a low performance on the tests was constantly higher in exposed subjects. When taking into account educational level, age, sex, alcohol consumption, smoking, environmental exposures, and depressive symptoms and when restricting analysis to subgroups, results remained significant for most tests, with odds ratios (OR) exceeding 2. These results point to long-term cognitive effects of low-level exposure to pesticides in occupational conditions. Given the frequency of pesticide use and the potential disabilities resulting from cognitive impairments, further toxicologic and epidemiologic research is needed to confirm these results and assess the impact on public health.