Self-assembled zinc phthalocyanine nanoparticles as excellent photothermal/photodynamic synergistic agent for antitumor treatment
Self-assembled zinc phthalocyanine nanoparticles as excellent photothermal/photodynamic synergistic agent for antitumor treatment
复制标题
自组装锌酞菁纳米粒子作为抗肿瘤治疗的优异光热/光动力协同剂
DOI：
10.1016/j.cej.2018.12.007
复制
发表时间：
2019
影响因子：
15.1
通讯作者：
Yang Piaoping
中科院分区：
文献类型：
--
作者：
Wang Zhao;Gai Shili;Wang Chuanqing;Yang Guixin;Zhong Chongna;Dai Yunlu;He Fei;Yang Dan;Yang Piaoping
由光敏剂分子组装而成的多功能光治疗诊断纳米粒子在肿瘤光治疗领域引起了广泛的关注.然而，大多数自组装光敏剂纳米颗粒仅表现出光热治疗（PTT）活性，而其光动力治疗（PDT）活性受到很大限制。在这里，我们首先获得了纳米结构的ZnPc组件与双峰PTT和PDT功能后，暴露于单色650 nm近红外（NIR）照射。所制备的ZnPc纳米粒子不仅具有良好的稳定性、良好的生物相容性和在适当的近红外区的吸收性，而且具有较高的光热转换效率（高达31.3%）和显著的PDT性能。合成方法简单，PTT和PDT协同作用的显著疗效，使ZnPc纳米粒子成为临床研究中安全有效的肿瘤光治疗剂。
Multifunctional phototheranostic nanoparticles assembled from photosensitizer molecules have attracted considerable attention the field of tumor phototherapies. However, most self-assembled photosensitizer nanoparticles only exhibit photothermal therapy (PTT) activity, while their photodynamic therapy (PDT) activity is greatly restricted. Here, we first obtained nanostructured ZnPc assemblies with dual-modal PTT and PDT functions upon exposure to monochromatic 650 nm near-infrared (NIR) irradiation. The as-prepared ZnPc nanoparticles not only showed good stability, excellent biocompatibility, and absorption in the appropriate NIR region, but also exhibited high photothermal conversion efficiency (as high as 31.3%) and remarkable PDT performance. The simple synthesis method and outstanding therapeutic effect from synergistic PTT and PDT make the as-obtained ZnPc nanoparticles an ideal phototheranostic agent for effective and safe cancer treatment in clinical research.