Effect of Preventive Supplementation With Ready-to-Use Therapeutic Food on the Nutritional Status, Mortality, and Morbidity of Children Aged 6 to 60 Months in Niger A Cluster Randomized Trial
Effect of Preventive Supplementation With Ready-to-Use Therapeutic Food on the Nutritional Status, Mortality, and Morbidity of Children Aged 6 to 60 Months in Niger A Cluster Randomized Trial
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DOI：
10.1001/jama.2008.1018
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发表时间：
2009-01-21
影响因子：
120.7
通讯作者：
Grais, Rebecca F.
中科院分区：
文献类型：
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作者：
Isanaka, Sheila;Nombela, Nohelly;Grais, Rebecca F.
研究背景即用型食疗食品（RUTFs）是门诊治疗严重消瘦症的重要组成部分.然而，他们的有效性，以人口为基础的预防中度和重度wasting.Objective尚未评估的影响，3个月的分布RUTF的营养状况，死亡率和发病率的6至60个月的儿童在尼日尔。设计，设置，和参与者一个群集随机试验的12个村庄在马拉迪，尼日尔。6个村庄被随机分为干预组和无干预组。在6个干预村中，体重身高比为国家卫生统计中心参考中位数80%或以上的干预儿童从2006年8月至10月接受了每月1包RUTF（92 g [ 500 kcal/ d]）的分发. 6个未干预村庄的儿童未接受预防性补充。从2006年8月至2007年3月，在所有12个研究村庄每月进行一次需要药物或营养治疗的情况的主动监测。主要结果测量根据世界卫生组织儿童生长标准的身高体重z评分（WHZ）的变化和消瘦发生率（WHZ
Context Ready- to- use therapeutic foods ( RUTFs) are an important component of effective outpatient treatment of severe wasting. However, their effectiveness in the population-based prevention of moderate and severe wasting has not been evaluated.Objective To evaluate the effect of a 3- month distribution of RUTF on the nutritional status, mortality, and morbidity of children aged 6 to 60 months in Niger.Design, Setting, and Participants A cluster randomized trial of 12 villages in Maradi, Niger. Six villages were randomized to intervention and 6 to no intervention. All children in the study villages aged 6 to 60 months were eligible for recruitment.Intervention Children with weight- for- height 80% or more of the National Center for Health Statistics reference median in the 6 intervention villages received a monthly distribution of 1 packet per day of RUTF ( 92 g [ 500 kcal/ d]) from August to October 2006. Children in the 6 nonintervention villages received no preventive supplementation. Active surveillance for conditions requiring medical or nutritional treatment was conducted monthly in all 12 study villages from August 2006 to March 2007.Main Outcome Measures Changes in weight- for- height z score ( WHZ) according to the World Health Organization Child Growth Standards and incidence of wasting ( WHZ