Defining Sickle Cell Disease Mortality Using a Population-Based Surveillance System, 2004 through 2008
Defining Sickle Cell Disease Mortality Using a Population-Based Surveillance System, 2004 through 2008
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DOI：
10.1177/003335491613100221
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发表时间：
2016-03-01
影响因子：
3.3
通讯作者：
Hulihan, Mary M.
中科院分区：
文献类型：
--
作者：
Paulukonis, Susan T.;Eckman, James R.;Hulihan, Mary M.
客观的。将加利福尼亚州和佐治亚州 2004 年至 2008 年基于人口的监测数据与州死亡记录文件联系起来，以确定 12,143 名镰状细胞病 (SCD) 患者的全因死亡率。方法。将这些 SCD 患者的按年龄划分的全因死亡率与非裔美国人和这两个州总人口的全因死亡率进行了比较。还将全因死亡率与来自公开死亡记录的 SCD 死亡率进行了比较：压缩的死亡率文件和多死因文件。结果。在 12,143 名确诊患有 SCD 的患者中，有 615 名患者死亡。 SCD人群的全因死亡率低于非裔美国人的全因死亡率，与出生至4岁的总人口全因死亡率相似，但SCD患者的全因死亡率高于非裔美国人和5岁至74岁总人口的死亡率。使用基于人群的监测数据确定的死亡患者数量 (n=615) 是仅使用 SCD 作为根本死因的压缩死亡率文件中确定的死亡患者数量 (n=297) 的两倍多。结论。准确评估全因死亡率和死亡年龄需要通过基于人群的登记对准确诊断的 SCD 患者进行长期监测。
Objective. Population-based surveillance data from California and Georgia for years 2004 through 2008 were linked to state death record files to determine the all-cause death rate among 12,143 patients identified with sickle cell disease (SCD).Methods. All-cause death rates, by age, among these SCD patients were compared with all-cause death rates among both African Americans and the total population in the two states. All-cause death rates were also compared with death rates for SCD derived from publicly available death records: the compressed mortality files and multiple cause of death files.Results. Of 12,143 patients identified with SCD, 615 patients died. The all-cause mortality rate for the SCD population was lower than the all-cause mortality rate among African Americans and similar to the total population all-cause mortality rates from birth through age 4 years, but the rate was higher among those with SCD than both the African American and total population rates from ages 5 through 74 years. The count of deceased patients identified by using population-based surveillance data (n=615) was more than twice as high as the count identified in compressed mortality files using SCD as the underlying cause of death alone (n=297).Conclusion. Accurate assessment of all-cause mortality and age at death requires long-term surveillance via population-based registries of patients with accurately diagnosed SCD.