X-ray-Induced Singlet Oxygen Activation with Nanoscintillator-Coupled Porphyrins
X-ray-Induced Singlet Oxygen Activation with Nanoscintillator-Coupled Porphyrins
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DOI：
10.1021/jp4077189
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发表时间：
2013-10-17
影响因子：
3.7
通讯作者：
Dujardin, Christophe
中科院分区：
文献类型：
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作者：
Bulin, Anne-Laure;Truillett, Charles;Dujardin, Christophe
涂有聚硅氧烷层的Tb2O3是一种生物相容性纳米闪烁剂，其在注射后表现出适当的生物分布模式。在这方面的贡献，我们结合联合收割机这种纳米系统与卟啉分子，能够产生单线态氧，一个主要的细胞毒性剂的光动力治疗应用。使用时间分辨激光光谱和单线态氧探针，我们证明了这种组合是适合于由X射线诱导的单线态氧产生，并提供了一个物理研究的纳米闪烁体和卟啉之间观察到的能量转移。结合放射治疗方案，所提出的纳米混合系统呈现出物理，化学和生物学特性的组合，使其成为深部组织中光动力效应的良好候选者。
Tb2O3 coated with a polysiloxane layer is a biocompatible nanoscintillator that exhibits an appropriate pattern of biodistribution after injection. In this contribution, we combine this nanosystem with porphyrin molecules that are able to generate singlet oxygen, a major cytotoxic agent for photodynamic therapy application. Using time-resolved laser spectroscopy and singlet oxygen probes, we demonstrate this combination is suitable for singlet oxygen generation induced by X-ray and provide a physical study of the energy transfer observed between the nanoscintillator and the porphyrin. Combined with a radiotherapy protocol, the proposed nanohybrid system presents a combination of physical, chemical, and biological properties that make it a good candidate for photodynamic effects in deep tissues.