Progress on development of the Nimbus-University of Pittsburgh axial flow left ventricular assist system.
Progress on development of the Nimbus-University of Pittsburgh axial flow left ventricular assist system.
复制标题
Nimbus-匹兹堡大学轴流左心室辅助系统的开发进展。
DOI：
10.1097/00002480-199809000-00040
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Antaki,JF
中科院分区：
文献类型：
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作者：
Thomas,DC;Butler,KC;Taylor,LP;LeBlanc,P;Rintoul,TC;Petersen,TV;Griffith,BP;Kormos,RL;Borovetz,HS;Litwak,P;Kameneva,MV;Choi,S;Burgreen,GW;Wu,Z;Antaki,JF
光轮公司（Rancho Cordova，CA）和匹兹堡大学已经完成了美国国立卫生研究院创新心室辅助系统计划下完全植入式轴流式血泵的第二年开发。今年的重点是完成泵的液压开发和解决其他关键系统部件的开发。在证明了令人满意的泵液压和生物相容性性能后，泵的开发集中在提高泵可制造性的设计特征上。一个具有全冗余功能的控制器已经设计完成，并处于试验板测试阶段。该电路的初始印刷电路布局表明，其尺寸为5× 6 cm，与植入兼容。完全植入式系统需要使用经皮能量Transformer系统（TETS）和诊断遥测系统。TETS电源电路经过重新设计，采用了改进的、更可靠的操作拓扑。遥测电路正在进行特性测试。闭环速度控制算法正在体外和体内进行测试，取得了良好的成功。进行了11次体内试验，持续时间从1天到195天。Endurance泵已通过6个月间隔期，轴承磨损极小。该计划的所有方面继续在正式的质量保证下运作。
Nimbus Inc.(Rancho Cordova, CA) and the University of Pittsburgh have completed the second year of development of a totally implanted axial flow blood pump under the National Institutes of Health Innovative Ventricular Assist System Program. The focus this year has been on completing pump hydraulic development and addressing the development of the other key system components. Having demonstrated satisfactory pump hydraulic and biocompatibility performance, pump development has focused on design features that improve pump manufacturability. A controller featuring full redundancy has been designed and is in the breadboard test phase. Initial printed circuit layout of this circuit has shown it to be appropriately sized at 5× 6 cm to be compatible with implantation. A completely implantable system requires the use of a transcutaneous energy transformer system (TETS) and a diagnostic telemetry system. The TETS power circuitry has been redesigned incorporating an improved, more reliable operating topography. A telemetry circuit is undergoing characterization testing. Closed loop speed control algorithms are being tested in vitro and in vivo with good success. Eleven in vivo tests were conducted with durations from 1 to 195 days. Endurance pumps have passed the 6 month interval with minimal bearing wear. All aspects of the program continue to function under formal quality assurance.