Mechanosensitive ion channels in cell migration.
Mechanosensitive ion channels in cell migration.
复制标题
细胞迁移中的机械敏感离子通道。
DOI：
10.1016/j.cdev.2021.203683
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发表时间：
2021-06
影响因子：
3.9
通讯作者：
Mayor R
中科院分区：
文献类型：
--
作者：
Canales Coutiño B;Mayor R
细胞过程由不同的刺激启动和调节，包括机械力。细胞膜机械传感器代表了将机械刺激转化为生物化学或电响应的第一步。机械敏感（MS）离子通道形成一个不断增长的离子门控通道家族，对直接的物理力或质膜变形作出反应。已知许多钙（Ca2+）渗透性MS通道在发育和肿瘤进展期间调节细胞迁移的起始、方向和持续。虽然将单个MS离子通道与细胞迁移联系起来的证据越来越多，但缺乏对MS离子通道激活下游调控的分子机制的统一分析。在这篇综述中，我们描述了已知的MS离子通道家族调节细胞迁移。我们讨论的分子机制，作用下游的MS离子通道的Ca2+介导的过程的重点。最后，我们提出了MS离子通道活性在细胞迁移领域的未来发展方向和影响。细胞过程由不同的刺激启动和调节，包括机械力。机械敏感性（MS）离子通道形成响应物理力或质膜变形的通道家族。已知许多MS通道调节细胞迁移的起始、方向和持续。
Cellular processes are initiated and regulated by different stimuli, including mechanical forces. Cell membrane mechanosensors represent the first step towards the conversion of mechanical stimuli to a biochemical or electrical response. Mechanosensitive (MS) ion channels form a growing family of ion gating channels that respond to direct physical force or plasma membrane deformations. A number of calcium (Ca2+) permeable MS channels are known to regulate the initiation, direction, and persistence of cell migration during development and tumour progression. While the evidence that links individual MS ion channels to cell migration is growing, a unified analysis of the molecular mechanisms regulated downstream of MS ion channel activation is lacking. In this review, we describe the MS ion channel families known to regulate cell migration. We discuss the molecular mechanisms that act downstream of MS ion channels with an emphasis on Ca2+ mediated processes. Finally, we propose the future directions and impact of MS ion channel activity in the field of cell migration. Cellular processes are initiated and regulated by different stimuli, including mechanical forces. Mechanosensitive (MS) ion channels form a family of channels that respond to physical force or plasma membrane deformations. A number of MS channels are known to regulate the initiation, direction and persistence of cell migration.
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影响因子：
5.3
作者：
Che H;Xiao GS;Sun HY;Wang Y;Li GR
通讯作者：
Li GR
影响因子：
16.6
作者：
Dong, Xian-ping;Shen, Dongbiao;Wang, Xiang;Dawson, Taylor;Li, Xinran;Zhang, Qi;Cheng, Xiping;Zhang, Yanling;Weisman, Lois S.;Delling, Markus;Xu, Haoxing
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Xu, Haoxing
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5.6
作者：
Bomben, Valerie C.;Turner, Kathryn L.;Barclay, Tia-Tabitha C.;Sontheimer, Harald
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Sontheimer, Harald
影响因子：
8
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通讯作者：
Thodeti CK
影响因子：
64.8
作者：
Barriga EH;Franze K;Charras G;Mayor R
通讯作者：
Mayor R