Validation of soy protein estimates from a food-frequency questionnaire with repeated 24-h recalls and isoflavonoid excretion in overnight urine in a Western population with a wide range of soy intakes
Validation of soy protein estimates from a food-frequency questionnaire with repeated 24-h recalls and isoflavonoid excretion in overnight urine in a Western population with a wide range of soy intakes
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DOI：
10.1093/ajcn/87.5.1422
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发表时间：
2008-05-01
影响因子：
7.1
通讯作者：
Sabate, Joan
中科院分区：
文献类型：
--
作者：
Jaceldo-Siegl, Karen;Fraser, Gary E.;Sabate, Joan
背景：关于大豆对西方人群癌症风险有益的证据并不一致，部分原因是这些群体的大豆摄入量较低。目的：我们评估了 Adventist Health Study-2 参与者样本中食物频率问卷 (FFQ) 中大豆蛋白估计值的有效性，这些参与者具有广泛的大豆摄入量。设计：我们获得了 100 名男性和女性（43 名黑人和 57 名非黑人）的膳食摄入数据。将 FFQ 中的大豆蛋白估计值与重复 24 小时回忆和尿中黄豆苷元、染料木黄酮、总异黄酮 (TIFL) 和雌马酚（通过 HPLC/光电二极管阵列/质谱法测量）的排泄物进行比较，作为参考标准。我们计算了 FFQ-24 小时回忆、24 小时回忆-尿液排泄和 FFQ-尿液排泄对的 Pearson 和 Spearman 相关系数（95% CI）。 结果：在大豆使用者中，24 小时回忆的平均 (+/- SD) 大豆蛋白值为 12.12 +/- 10.80 g/d，9.43 +/- 7.83 g/d 来自 FFQ。 24 小时召回的大豆蛋白估计值与 FFQ 之间的未衰减相关性 (95% CI) 为 0.57 (0.32, 0.75)。 24 小时回忆的大豆蛋白摄入量与尿异黄酮类化合物之间的相关系数分别为：大豆黄酮为 0.72（0.43，0.96），金雀异黄酮为 0.67（0.43，0.91），TIFL 为 0.72（0.47，0.98）。在 FFQ 和尿排泄之间，大豆苷元、染料木黄酮和 TIFL 的值分别为 0.50 (0.32, 0.65)、0.48 (0.29, 0.61) 和 0.50 (0.32, 0.64)。结论：问卷中的大豆蛋白估计值与 24 小时回忆和尿排泄中的大豆蛋白显着相关。大豆黄酮、染料木黄酮和 TIFL。 Adventist Health Study-2 FFQ 是评估大豆摄入量广泛的人群中大豆蛋白的有效工具。
Background: Evidence of the benefits of soy on cancer risk in Western populations is inconsistent, in part because of the low intake of soy in these groups.Objective: We assessed the validity of soy protein estimates from food-frequency questionnaires (FFQs) in a sample of Adventist Health Study-2 participants with a wide range of soy intakes.Design: We obtained dietary intake data from 100 men and women (43 blacks and 57 nonblacks). Soy protein estimates from FFQs were compared against repeated 24-h recalls and urinary excretion of daidzein, genistein, total isoflavonoids (TIFLs), and equol (measured by HPLC/photodiode array/mass spectrometry) as reference criteria. We calculated Pearson and Spearman correlation coefficients (with 95% CIs) for FFQ-24-h recall, 24 h-recall-urinary excretion, and FFQ-urinary excretion pairs.Results: Among soy users, mean (+/- SD) soy protein values were 12.12 +/- 10.80 g/d from 24-h recalls and 9.43 +/- 7.83 g/d from FFQs. The unattenuated correlation (95% CI) between soy protein estimates from 24-h recalls and FFQs was 0.57 (0.32, 0.75). Correlation coefficients between soy protein intake from 24-h recalls and urinary isoflavonoids were 0.72 (0.43, 0.96) for daidzein, 0.67 (0.43, 0.91) for genistein, and 0.72 (0.47, 0.98) for TIFLs. Between FFQs and urinary excretion, these were 0.50 (0.32, 0.65), 0.48 (0.29, 0.61), and 0.50 (0.32, 0.64) for daidzein, genistein, and TIFLs, respectively.Conclusions: Soy protein estimates from questionnaire were significantly correlated with soy protein from 24-h recalls and urinary excretion of daidzein, genistein, and TIFLs. The Adventist Health Study-2 FFQ is a valid instrument for assessing soy protein in a population with a wide range of soy intakes.