Two cases of nonbacterial cystitis associated with nivolumab, the anti-programmed-death-receptor-1 inhibitor.
Two cases of nonbacterial cystitis associated with nivolumab, the anti-programmed-death-receptor-1 inhibitor.
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DOI：
10.1016/j.eucr.2017.12.006
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发表时间：
2018-03
影响因子：
0.5
通讯作者：
Kanematsu A
中科院分区：
文献类型：
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作者：
Shimatani K;Yoshimoto T;Doi Y;Sonoda T;Yamamoto S;Kanematsu A
3.讨论这是第一份关于与免疫检查点抑制剂给药相关的非细菌性膀胱炎的报告。在这两个病例中，长期纳武单抗治疗后出现类似的排尿疼痛和非细菌性脓尿等症状。症状和脓尿与纳武单抗给药同时发生，并通过口服泼尼松龙迅速改善。因此，两名患者均被认为经历了与纳武利尤单抗相关的免疫相关不良反应（irAE）。
3. DiscussionThis is the first report on non-bacterial cystitis associated with the administration of an immune checkpoint inhibitor. In the two presented cases, symptoms such as micturition pain and nonbacterial pyuria appeared similarly after long-term nivolumab treatment. The symptoms and pyuria coincided with nivolumab administration and rapidly improved by taking oral prednisolone. Therefore, both patients were considered to have experienced immune-related adverse effects (irAEs) related to nivolumab.