Polymers in Drug Delivery-State of the Art and Future Trends
Polymers in Drug Delivery-State of the Art and Future Trends
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DOI：
10.1002/adem.201080088
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发表时间：
2011-03-01
影响因子：
3.6
通讯作者：
Fischer, Dagmar
中科院分区：
文献类型：
--
作者：
Grund, Stefan;Bauer, Marius;Fischer, Dagmar
生物技术、蛋白质组学和基因组学的进步，以及对病理生理状态的分子和细胞基础的更深入理解，使得新型药物如蛋白质、肽和核酸的开发成为未来的治疗策略。然而，它们的应用需要复杂的药物递送系统，其可用于改变药物的药代动力学和释放特性，并增加组织特异性和生物相容性。在这种情况下，聚合物提供了最有前途的途径，在药物释放控制，由于其有利的，可调的特性，并进一步修改的可能性。生物医学科学的进步对设计和开发新的智能药物递送系统产生了重大影响，以实现更可控和更有针对性的药物应用。本文综述了聚合物在药物释放中的应用现状，重点介绍了聚合物的结构-性能关系，并对各种聚合物及其在药物释放中的相关参数进行了综述，最后展望了聚合物在药物释放中的应用前景。
Advances in biotechnology, proteomics, and genomics, as well as the deeper understanding of the molecular and cellular bases of pathophysiological states, have allowed the development of novel drugs such as proteins, peptides, and nucleic acids as therapeutic strategies of the future. Their application, however, requires sophisticated drug delivery systems which can be used to alter the pharmacokinetics and release characteristics of drugs, and to increase tissue specificity and biocompatibility. In this context, polymers provide the most promising avenue in drug release control due to their favorable, adjustable characteristics, and possibilities for further modification. Advances in the biomedical sciences have had a significant impact on the design and development of new and intelligent drug delivery systems for more controlled and targeted drug application. This review summarizes the status quo of polymer use for drug delivery with a special focus on structure-property relationships and gives overviews of various polymers, the relevant parameters in drug delivery and the most promising trends in the future.