Skin Ultrastructural Findings in Acquired Generalized Hypohidrosis/Anhidrosis in a Patient with Subclinical Sjögren Syndrome.
Skin Ultrastructural Findings in Acquired Generalized Hypohidrosis/Anhidrosis in a Patient with Subclinical Sjögren Syndrome.
复制标题
亚临床干燥综合征患者获得性全身性少汗/无汗症的皮肤超微结构发现。
DOI：
10.2340/00015555-2690
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发表时间：
2017
影响因子：
3.6
通讯作者：
Sebastian Yu
中科院分区：
文献类型：
--
作者：
Yu;Pei;T. Huang;H‐S. Yu;Y. Hsieh;Sebastian Yu
Sjögren综合征（SS）是一种以外分泌功能障碍为特征的自身免疫性疾病，如干眼症或口干症，局灶性淋巴细胞性涎腺炎，以及包括抗ro和抗la在内的高滴度自身抗体。SS也与器质性皮肤病和神经病变有关。皮肤干燥是23-67%的SS患者的并发症，尤其是50岁以下的患者(1)。2例获得性全身性少汗/无汗症（AGHA）与亚临床SS和眼睛和嘴巴不干燥有关（2,3）。此外，包括自主神经病变在内的周围神经病变是SS最常见的神经系统并发症，患病率从小于2%到大于60%不等(4)。植物神经病变可引起直立性低血压、肠功能障碍和无汗等症状。我们在此报告一例亚临床ss相关性AGHA。
Sjögren’s syndrome (SS) is an autoimmune disorder characterized by exocrine dysfunction, such as xero phthalmia or xerostomia, focal lymphocytic sialoadenitis, and a high titre of autoantibodies inclusive of antiRo and antiLa. SS is also associated with both organic dermatological disorders and neuropathy. Dry skin is a complication in 23–67% of patients with SS, especially those under 50 years of age (1). Two cases of acquired generalized hypohidrosis/anhidrosis (AGHA) associated with subclinical SS and absence of dryness of the eyes and mouth have been described previously (2, 3). In addition, peripheral neuropathy, the spectrum of which includes autonomic neuropathy, is the most common neu rological complication of SS, with a prevalence ranging from less than 2% to greater than 60% (4). Autonomic neuropathy may cause symptoms such as orthostatic hypotension, bowel dysfunction and anhidrosis. We report here a case of subclinical SSassociated AGHA.
胆碱能荨麻疹：无汗和少汗皮肤中毒蕈碱胆碱能受体 M3 的研究
影响因子：
6.5
作者：
Sawada Y;Nakamura M;Bito T;Fukamachi S;Kabashima R;Sugita K;Hino R;Tokura Y
通讯作者：
Tokura Y