Evidence for decreased GDP binding to brown-adipose-tissue mitochondria of obese Zucker (fa/fa) rats in the very first days of life.
Evidence for decreased GDP binding to brown-adipose-tissue mitochondria of obese Zucker (fa/fa) rats in the very first days of life.
复制标题
有证据表明，肥胖 Zucker (fa/fa) 大鼠在出生后的第一天，GDP 与棕色脂肪组织线粒体的结合减少。
DOI：
10.1042/bj2210241
复制
发表时间：
1984
期刊：
影响因子：
--
通讯作者：
M. Lavau
中科院分区：
文献类型：
--
作者：
R. Bazin;D. Eteve;M. Lavau
2-14 天的肥胖 Zucker 大鼠 (fa/fa) 幼崽的 GDP 与棕色脂肪组织线粒体的结合显着低于瘦对照大鼠。 Scatchard 对 10 天大幼崽的分析表明 GDP 结合位点大幅减少。然而，两天大的肥胖前期幼犬棕色脂肪组织中的脂肪含量显着增加，引发了这两种紊乱之间的顺序和因果关系的问题。
GDP binding to brown-adipose-tissue mitochondria of obese Zucker-rat (fa/fa) pups aged 2-14 days was significantly less than in lean control rats. Scatchard analysis in 10-day-old pups suggests that there was a large decrease in GDP-binding sites. However, a significant increase in fat content in brown adipose tissue of 2-day-old pre-obese pups raised the question of the sequential order and causal relationship between these two derangements.