Proton transport by proteorhodopsin requires that the retinal Schiff base counterion Asp-97 be anionic
Proton transport by proteorhodopsin requires that the retinal Schiff base counterion Asp-97 be anionic
复制标题
DOI：
10.1021/bi034253r
复制
发表时间：
2003-06-03
期刊：
影响因子：
2.9
通讯作者：
Lanyi, JK
中科院分区：
文献类型：
--
作者：
Dioumaev, AK;Wang, JM;Lanyi, JK
在pH> 7时，蛋白视紫红质在细胞膜中充当外向质子泵，而细菌视紫红质中的Asp-85和Asp-96的同系物Asp-97和Glu-108分别是视紫红质席夫碱的质子受体和供体。据报道，然而[弗里德里希，T。等人（2002）J. Mol.生物学：321，821 - 838]，蛋白视紫质也在pH下运输质子
At pH >7, proteorhodopsin functions as an outward-directed proton pump in cell membranes, and Asp-97 and Glu-108, the homologues of the Asp-85 and Asp-96 in bacteriorhodopsin, are the proton acceptor and donor to the retinal Schiff base, respectively. It was reported, however [Friedrich, T. et al. (2002) J. Mol. Biol., 321, 821-838], that proteorhodopsin transports protons also at pH