GLUTAMATERGIC AXONS FROM THE LATERAL HABENULA MAINLY TERMINATE ON GABAergic NEURONS OF THE VENTRAL MIDBRAIN
GLUTAMATERGIC AXONS FROM THE LATERAL HABENULA MAINLY TERMINATE ON GABAergic NEURONS OF THE VENTRAL MIDBRAIN
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DOI：
10.1016/j.neuroscience.2010.03.050
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发表时间：
2010-06-30
期刊：
影响因子：
3.3
通讯作者：
Veh, R. W.
中科院分区：
文献类型：
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作者：
Brinschwitz, K.;Dittgen, A.;Veh, R. W.
皮质-皮质下环的概念强调了基底神经节对于运动、精神和情感皮质功能的重要性。这些回路由中脑多巴胺能系统双向控制，主要但不完全在纹状体水平，包括纹状体核。成功的行为增加了中纹状体（出现在黑质的复杂部分）和中脑边缘（出现在腹侧被盖区，VTA）神经元的活动，从而加强了相应的行动。相反，不成功的行为导致外侧缰复合体（LHb）的激活增加，从而降低了中脑边缘神经元的活动。相应地，LHb的电刺激有效地阻断VTA中的神经元活动。这种阻滞是否是由于从LHb到VIA的抑制性投射，或者来自兴奋性LHb神经元的轴突是否靶向腹侧被盖区内的抑制性神经元，目前尚不清楚。在这里，我们表明，使用原位杂交和免疫细胞化学双标记在光镜和电镜水平，GABA能神经元是稀缺的LHb和LHb的GABA能轴突主要针对在VIA和中桥脑头内侧被盖核（RMTg），也被称为尾的VIA（tVTA）的GABA能神经元。这些数据解释了LHb激活对VIA的抑制作用。然而，除此之外，VIA中的少数LHb终末实际上与多巴胺能神经元接触。这些终端的生物重要性需要进一步调查。(C)2010年IBRO。由爱思唯尔有限公司出版。保留所有权利。
The concept of cortical-subcortical loops emphasizes the importance of the basal ganglia for motor, psychomotor, and emotional cortical functions. These loops are bidirectionally controlled by the midbrain dopaminergic system, predominantly but not exclusively at the level of the striatum including the accumbens nucleus. Successful behaviors increase the activities of the mesostriatal (arising in the complex part of the substantia nigra) and mesolimbic (arising in the ventral tegmental area, VTA) neurons, thereby reinforcing the corresponding actions. In contrast, unsuccessful behaviors result in an increased activation of the lateral habenular complex (LHb), thereby decreasing the activities of mesolimbic neurons. Correspondingly, electrical stimulation of the LHb effectively blocks neuronal activity in the VTA. Whether this block is due to an inhibitory projection from the LHb to the VIA, or whether axons from excitatory LHb neurons target inhibitory neurons within the VTA, is presently not known. Here we show, using in situ hybridization and immunocytochemical double labeling at the light and electron microscopic level, that GABAergic neurons are scarce in the LHb and that glutamatergic axons from the LHb mostly target GABAergic neurons in the VIA and the mesopontine rostromedial tegmental nucleus (RMTg), also known as tail of the VIA (tVTA). These data explain the inhibitory effect of LHb activation on the VIA. In addition, however, a small number of LHb terminals in the VIA actually contacts dopaminergic neurons. The biological importance of these terminals requires further investigation. (C) 2010 IBRO. Published by Elsevier Ltd. All rights reserved.