Electrical stimulation of the nigrostriatal pathway after HA-966 block of triatal dopamine release.
Electrical stimulation of the nigrostriatal pathway after HA-966 block of triatal dopamine release.
复制标题
HA-966 阻断三体多巴胺释放后对黑质纹状体通路的电刺激。
DOI：
10.1016/0014-2999(78)90326-6
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发表时间：
1978
影响因子：
5
通讯作者：
E. L. Noach
中科院分区：
文献类型：
--
作者：
C. V. van Valkenburg;E. L. Noach
大鼠纹状体多巴胺（DA）在黑质电解损伤（SN）或全身给药1-羟基-3-氨基吡罗烷酮-2 （HA-966）阻断DA释放后1小时增加两倍。如果联合治疗，则没有观察到进一步的增加。α-甲基-对酪氨酸（αMT）诱导的DA降低在未处理的动物中，对黑质纹状体纤维进行20分钟的电刺激并没有增强。然而，如果除了αMT的合成阻断外，DA的释放被SN损伤和/或HA-966中断，电刺激会导致纹状体DA的显著降低。推测HA-966在多巴胺能黑质纹状体系统中发挥作用的途径是在SN水平上阻断神经冲动流。
Striatal dopamine (DA) of rats increased twofold 1 h after blockade of DA release by either an electrolytic lesion of the substantia nigra (SN) or systemic administration of 1-hydroxy-3-amino-pyrrolidone-2 (HA-966). If the treatments were combined, no further increase was observed. The decrease in DA induced by α-methyl-p-tyrosine (αMT) in otherwise untreated animals was not enhanced by a 20 min electrical stimulation of nigrostriatal fibres. If, however, in addition to synthesos blockade by αMT, DA release was interrupted by a lesion of the SN and/or by HA-966, electrical stimulation caused a significant decrease in striatal DA. It is assumed that HA-966 exerts its action in the dopaminergic nigrostriatal system by way of blockade of the nerve impulse flow at the level of the SN.