Increased lymphocyte to monocyte ratio is associated with better prognosis in patients with newly diagnosed metastatic nasopharyngeal carcinoma receiving chemotherapy
Increased lymphocyte to monocyte ratio is associated with better prognosis in patients with newly diagnosed metastatic nasopharyngeal carcinoma receiving chemotherapy
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DOI：
10.1007/s13277-014-2362-6
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发表时间：
2014-11-01
期刊：
影响因子：
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通讯作者：
Chen, Xiao-Qin
中科院分区：
文献类型：
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作者：
Lin, Gui-Nan;Peng, Jie-Wen;Chen, Xiao-Qin
炎症反应广泛参与了鼻咽癌的发生发展过程。然而，淋巴细胞与单核细胞比率（LMR）在转移性NPC中的预后意义尚未完全解决。本研究的目的是探讨治疗前绝对淋巴细胞计数（ALC），绝对单核细胞计数（AMC）和LMR对接受化疗的新诊断转移性NPC患者的预后影响。回顾性收集2006年1月至2010年12月期间接受化疗的新诊断转移性NPC患者。研究了基线临床特征和炎症标志物的预后意义。共有256例患者符合研究条件。ALC、AMC和LMR的最佳临界值分别为2.25 x 10（9）/L、0.35 x 10（9）/L和5.07。高LMR组患者的总生存期（OS）（25.0个月[24.50-25.49]）显著长于低LMR组患者（16.0个月[15.51-16.49]; p < 0.001）。此外，ALC a千分之一日元欧元千分之2.25 x 10（9）/L（HR，0.59; 95% CI，0.43-0.81; p = 0.001）和LMR a千分之5.07（HR，0.42; 95% CI，0.30-0.59; p < 0.001）仍然是上级OS的独立预后因素，而AMC在考克斯多变量分析中没有保留其预后意义。治疗前ALC和LMR是影响初治转移性鼻咽癌化疗患者预后的独立因素。需要进一步的前瞻性研究来验证这些发现。
Inflammation has been demonstrated to be widely involved in the carcinogenesis of nasopharyngeal carcinoma (NPC). However, the prognostic significance of lymphocyte to monocyte ratio (LMR) in metastatic NPC is not fully addressed. The purpose of the study is to investigate the prognostic impact of pre-treatment absolute lymphocyte count (ALC), absolute monocyte count (AMC), and LMR on patients with newly diagnosed metastatic NPC undergoing chemotherapy. Between January 2006 and December 2010, patients with newly diagnosed metastatic NPC undergoing chemotherapy were retrospectively collected. The prognostic significance of baseline clinical features and inflammatory markers was investigated. A total of 256 patients were eligible for the study. The best cut-off value of ALC, AMC, and LMR was 2.25 x 10(9)/L, 0.35 x 10(9)/L, and 5.07, respectively. Patients in the high LMR group had a significantly longer overall survival (OS) (25.0 months [24.50-25.49]) than patients in the low LMR group (16.0 months [15.51-16.49]; p < 0.001). In addition, ALC a parts per thousand yenaEuro parts per thousand 2.25 x 10(9)/L (HR, 0.59; 95 % CI, 0.43-0.81; p = 0.001) and LMR a parts per thousand yen5.07 (HR, 0.42; 95 % CI, 0.30-0.59; p < 0.001) remained as independent prognostic factors for superior OS, while AMC did not retained its prognostic significance in COX multivariate analysis. Pre-treatment ALC and LMR were demonstrated to be independent prognostic factors in patient with newly diagnosed metastatic NPC receiving chemotherapy. Future prospective studies are needed to validate the findings.