De Novo Discovery of Structured ncRNA Motifs in Genomic Sequences
De Novo Discovery of Structured ncRNA Motifs in Genomic Sequences
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DOI：
10.1007/978-1-62703-709-9_15
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发表时间：
2014-01-01
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影响因子：
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通讯作者：
Gorodkin, Jan
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文献类型：
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作者：
Ruzzo, Walter L.;Gorodkin, Jan
从头发现捕获相关非编码结构rna之间共性的“基序”是计算生物学中最困难的问题之一。本章概述了这个问题所带来的挑战，以及解决这些问题的一些方法，重点介绍了基于CMfinder程序的方法作为案例研究。应用于基因组筛选新的从头开始的结构ncrna，包括在蛋白质编码基因的非翻译部分的结构RNA元件，提出。
De novo discovery of "motifs" capturing the commonalities among related noncoding structured RNAs is among the most difficult problems in computational biology. This chapter outlines the challenges presented by this problem, together with some approaches towards solving them, with an emphasis on an approach based on the CMfinder program as a case study. Applications to genomic screens for novel de novo structured ncRNAs, including structured RNA elements in untranslated portions of protein-coding genes, are presented.