Targeting the ACE2-Ang-(1-7) pathway in cardiac fibroblasts to treat cardiac remodeling and heart failure.
Targeting the ACE2-Ang-(1-7) pathway in cardiac fibroblasts to treat cardiac remodeling and heart failure.
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DOI：
10.1016/j.yjmcc.2010.12.003
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发表时间：
2011-10
影响因子：
5
通讯作者：
Greenberg B
中科院分区：
文献类型：
--
作者：
Iwata M;Cowling RT;Yeo SJ;Greenberg B
成纤维细胞通过细胞外基质（ECM）蛋白的沉积以及通过影响心肌细胞的生长和功能在心脏重塑和心力衰竭的发展中起关键作用。肾素-血管紧张素系统（RAS）是健康和疾病中心血管系统的关键调节因子，其许多作用涉及心脏成纤维细胞。RAS的主要效应分子血管紧张素II（Ang II）的水平在衰竭心脏中升高，并且有大量证据表明该肽有助于心脏结构和功能的变化，其最终导致心力衰竭的进行性恶化。涉及血管紧张素转化酶2（ACE 2）的途径具有分解Ang II同时产生血管紧张素-（1-7）（Ang-（1 - 7），一种七肽，其与Ang II相反，具有心脏保护和抗重塑作用。许多Ang-（1-7）作用涉及心脏成纤维细胞，并且有信息表明它减少胶原蛋白的产生并且还可以防止心脏肥大。本报告描述了ACE 2和Ang-（1-7）在心脏重塑和心力衰竭中的作用，并探讨了旨在增加ACE 2活性和Ang-（1-7）水平以治疗这些疾病的潜在治疗策略。
Fibroblasts play a pivotal role in cardiac remodeling and the development of heart failure through the deposition of extra-cellular matrix (ECM) proteins and also by affecting cardiomyocyte growth and function. The renin-angiotensin system (RAS) is a key regulator of the cardiovascular system in health and disease and many of its effects involve cardiac fibroblasts. Levels of angiotensin II (Ang II), the main effector molecule of the RAS, are elevated in the failing heart and there is a substantial body of evidence indicating that this peptide contributes to changes in cardiac structure and function which ultimately lead to progressive worsening in heart failure. A pathway involving angiotensin converting enzyme 2 (ACE2) has the capacity to break down Ang II while generating angiotensin-(1–7) (Ang-(1–7), a heptapeptide, which in contrast to Ang II, has cardioprotective and anti-remodeling effects. Many Ang-(1–7) actions involve cardiac fibroblasts and there is information indicating that it reduces collagen production and also may protect against cardiac hypertrophy. This report describes the effects of ACE2 and Ang-(1–7) that appear to be relevant in cardiac remodeling and heart failure and explores potential therapeutic strategies designed to increase ACE2 activity and Ang-(1–7) levels to treat these conditions.
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影响因子：
6.1
作者：
Ferreira, Anderson J.;Oliveira, Thauana L.;Santos, Robson A. S.
通讯作者：
Santos, Robson A. S.
影响因子：
24
作者：
Epelman, Slava;Tang, W. H. Wilson;Chen, Stephen Y.;Van Lente, Frederick;Francis, Gary S.;Sen, Subha
通讯作者：
Sen, Subha
影响因子：
5
作者：
Gurantz, D;Cowling, RT;Greenberg, BH
通讯作者：
Greenberg, BH
影响因子：
8.3
作者：
Dias-Peixoto, Marco F.;Santos, Robson A. S.;Guatimosim, Silvia
通讯作者：
Guatimosim, Silvia
影响因子：
5.7
作者：
Fraga-Silva, Rodrigo Araujo;Brant Pinheiro, Sergio Veloso;Souza Santos, Robson Augusto
通讯作者：
Souza Santos, Robson Augusto