Metabolic disorders and cardiovascular consequences of HIV infection and antiretroviral therapy.
Metabolic disorders and cardiovascular consequences of HIV infection and antiretroviral therapy.
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DOI：
10.1586/ecp.09.11
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发表时间：
2009-07-01
影响因子：
4.4
通讯作者：
Emery, Sean
中科院分区：
文献类型：
--
作者：
Martin, Allison;Emery, Sean
与艾滋病毒疾病相关的代谢紊乱已成为患者管理中的一个重要因素，并对死亡率和医疗负担方面的长期结果产生重要影响。最近的研究表明，艾滋病毒感染本身和特定的抗逆转录病毒治疗都与这些疾病的发展有关。本文综述了胰岛素和葡萄糖调节异常、血脂异常、脂肪组织和骨代谢紊乱等方面的最新研究成果。这篇综述随后描述了这些代谢紊乱的心血管后果和管理，并总结了目前对抗逆转录病毒治疗的发病机制和效果的看法。最后，本文就该领域的研究面临的挑战和未满足的需求提出了一些问题。
Metabolic disturbances associated with HIV disease have become an important factor in patient management and have important implications for long-term outcomes, both in regards to mortality and healthcare burden. Recent research has implicated both HIV infection itself and specific antiretroviral therapies in the development of these disorders. This review examines recent findings from research into insulin and glucose dysregulation, serum lipid abnormalities, adipose tissue and derangements in bone metabolism. This review then describes the cardiovascular consequences and management of these metabolic disorders, and summarizes current thinking on the pathogenesis and effects of antiretroviral therapy. Finally, the review raises some questions regarding ongoing challenges and unmet needs in this field of research.