Sex Differences in Congenital Heart Disease in Down Syndrome: Study Data from Medical Records and Questionnaires in a Region of Japan.
Sex Differences in Congenital Heart Disease in Down Syndrome: Study Data from Medical Records and Questionnaires in a Region of Japan.
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唐氏综合症先天性心脏病的性别差异：来自日本某地区医疗记录和调查问卷的研究数据。
DOI：
10.1136/bmjpo-2018-000414
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发表时间：
2019
影响因子：
2.6
通讯作者：
Haruyoshi Takaki et al.
中科院分区：
文献类型：
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作者：
Takako Takano;Michio Akagi;Haruyoshi Takaki et al.
报告表明，在澳大利亚，女性唐氏综合症（DS）的存活率低于男性，与一般人群中的女性寿命形成对比。利用日本5家医院1310名DS患者（626名女性和684名男性）的病历和DS患者父母完成的问卷调查数据，我们调查了先天性心脏病（CHD）的性别差异，这可能与死亡率有关。女性冠心病发生率（354，57%）显著高于男性（338，49%; p=0.010）。女性（199，32%）接受CHD手术的人数显著多于男性（175，26%）（p=0.018）。
Reports indicate lower Down syndrome (DS) survival among females than among males in Australia, contrasting with female longevity in the general population. Using data on 1310 people with DS (626 females and 684 males) in Japan from five hospitals’ medical records and questionnaires completed by parents of people with DS, we investigated sex differences in congenital heart disease (CHD), which may be related to mortality. The CHD rate was significantly higher for females (354, 57%) than for males (338, 49%; p=0.010). Significantly more females (199, 32%) than males (175, 26%) underwent surgery for CHD (p=0.018).