Fabrication of conductive electrospun silk fibroin scaffolds by coating with polypyrrole for biomedical applications
Fabrication of conductive electrospun silk fibroin scaffolds by coating with polypyrrole for biomedical applications
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DOI：
10.1016/j.bioelechem.2011.11.008
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发表时间：
2012-06-01
影响因子：
5
通讯作者：
Otero, Toribio F.
中科院分区：
文献类型：
--
作者：
Aznar-Cervantes, Salvador;Roca, Maria I.;Otero, Toribio F.
采用静电纺丝法制备了丝素微纤维和纳米纤维构成的支架。采用化学聚合法制备聚吡咯（pPy）包覆丝素网纤维；通过扫描电镜和红外光谱观察了聚合物之间的化学联系。采用聚吡咯涂层提高了网片的机械性能。此外，涂层网具有很高的电活性，允许阴离子在水溶液中的氧化/还原反应中储存和传递。未包被和pPy包被材料支持成体人间充质干细胞（ahMSCs）或人成纤维细胞（hFb）的粘附和增殖。丝素网的生物活性优于聚吡咯涂层网。(C) 2011 Elsevier BM。版权所有。
Scaffolds constituted by micro and nanofibers of silk fibroin were obtained by electrospinning. Fibers of fibroin meshes were coated with polypyrrole (pPy) by chemical polymerization; chemical linkages between polymers were observed by SEM and IR spectroscopy. Mechanical resistance of the meshes was improved by polypyrrole coating. Furthermore, coated meshes present a high electroactivity allowing anion storage and delivery during oxidation/reduction reactions in aqueous solutions. Uncoated and pPy coated materials support the adherence and proliferation of adult human mesenchymal stem cells (ahMSCs) or human fibroblasts (hFb). The bioactivity of fibroin mesh overcomes that of the polypyrrole coated meshes. (C) 2011 Elsevier BM. All rights reserved.