THE EFFECT OF ELECTRICAL STIMULATION UPON THE ACCUMULATION OF ADENOSINE 3′,5′‐PHOSPHATE IN ISOLATED CEREBRAL TISSUE
THE EFFECT OF ELECTRICAL STIMULATION UPON THE ACCUMULATION OF ADENOSINE 3′,5′‐PHOSPHATE IN ISOLATED CEREBRAL TISSUE
复制标题
电刺激对离体脑组织中3′,5′-磷酸腺苷积累的影响
DOI：
10.1111/j.1471-4159.1969.tb06847.x
复制
发表时间：
1969
影响因子：
4.7
通讯作者：
H. Mcilwain
中科院分区：
文献类型：
--
作者：
S. Kakiuchi;T. Rall;H. Mcilwain
将电脉冲应用于豚鼠大脑皮层切片，导致腺苷3′，5 ′-磷酸（环3′，5 ′-AMP）水平在10分钟内增加11倍以上。在茶碱存在下，电脉冲的这种作用严重降低。在去甲肾上腺素和组胺存在下，切片中的环3′，5 ′-AMP蓄积分别增加约1.5倍和6倍;在最大量的胺存在下，电脉冲的作用增强。由于这些和其他原因，电刺激诱导的环3′，5 ′-AMP蓄积不能归因于组胺或去甲肾上腺素的释放和作用。
The application of electrical pulses to slices of guinea pig cerebral cortex led to an increase in the levels of adenosine 3′,5′‐phosphate (cyclic 3′,5′‐AMP) of more than 11‐fold within 10 min. This effect of electrical pulses was severely reduced in the presence of theophylline. Cyclic 3′,5′‐AMP accumulation in slices was increased in the presence of norepinephrine and histamine about 1·5‐fold and six‐fold, respectively; the effect of electrical pulses was augmented in the presence of maximal amounts of either amine. For these and other reasons, the accumulation of cyclic 3′,5′‐AMP induced by electrical stimulation cannot be ascribed to the release and action of either histamine or norepinephrine.