Synergistic effects of betel quid chewing, tobacco use (in the form of cigarette smoking), and alcohol consumption on the risk of malignant transformation of oral submucous fibrosis (OSF): a case-control study in Hunan Province, China
Synergistic effects of betel quid chewing, tobacco use (in the form of cigarette smoking), and alcohol consumption on the risk of malignant transformation of oral submucous fibrosis (OSF): a case-control study in Hunan Province, China
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咀嚼槟榔、吸烟（以吸烟的形式）和饮酒对口腔粘膜下纤维化（OSF）恶变风险的协同作用：中国湖南省的一项病例对照研究
DOI：
10.1016/j.oooo.2015.04.013
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发表时间：
2015-09-01
影响因子：
2.9
通讯作者：
Jian, Xinchun
中科院分区：
文献类型：
--
作者：
Liu, Bowen;Shen, Minxue;Jian, Xinchun
目标.口腔粘膜下纤维性变（OSF）是一种潜在的恶性疾病，其中7%至13%的OSF患者在临床上确定患有OSF的同时部位发展为口腔鳞状细胞癌（OSCC）。我们的目的是调查与生活方式相关的OSF恶性转化的危险因素。选取2012年1月至2014年10月在湖南省湘雅医院就诊的80例OSF相关OSCC患者和80例无临床或组织病理学表现的OSF对照者，进行病例对照研究。在咀嚼槟榔（BQ）的最高暴露时间和频率下，OSCC的比值比（OR）分别为13.3（95%置信区间[95% CI]：3.1-56.4）和45.1（95% CI：9.6-212.9）。吸烟（OR = 5.0，95%CI：1.7-14.8）和饮酒（OR = 3.1，95%CI：1.1-8.6）也与较高的风险相关。同时服用BQ和香烟或酒精的患者的校正OR显著增加，分别为26.1（95%CI：4.0-172.6）和55. (95% CI：在最长持续时间时，分别为160.3（95%CI：18.7-11371.2）和58.1（95%CI：2.4-1434.9）。使用BQ、香烟和酒精被确定为中国大陆湖南省OSF恶变的危险因素。BQ咀嚼和香烟或酒精消费之间的协同效应被揭示。
Objectives. Oral submucous fibrosis (OSF) is a potentially malignant disorder, wherein 7% to 13% of patients with OSF develop oral squamous cell carcinoma (OSCC) at clinically coincident sites established to have OSF. We aimed at investigating the lifestyle-related risk factors for malignant transformation of OSF.Study Design. A case-control study was conducted among 80 cases with OSF-associated OSCC and 80 controls with OSF but without clinically or histopathologically evident OSCC, recruited from January 2012 to October 2014 in the Xiangya Hospital, Hunan Province, Mainland China.Results. The odds ratios (OR) for OSCC were 13.3 (95% confidence interval [95% CI]: 3.1-56.4) and 45.1 (95% CI: 9.6-212.9) at the highest exposure of betel quid (BQ) chewing, by duration and frequency, respectively. Higher risks were also found to be associated with the consumption of cigarette (OR = 5.0, 95% CI: 1.7-14.8) and alcohol (OR = 3.1, 95% CI: 1.1-8.6). Adjusted ORs increased substantially among patients who consumed BQ and cigarette or alcohol simultaneously, which were 26.1 (95% CI: 4.0-172.6) and 55.-(95% CI: 1.8-1742.8) at the longest duration, and 160.3 (95% CI: 18.7-11371.2) and 58.1 (95% CI: 2.4-1434.9) at the highest dose, respectively.Conclusions. The use of BQ, cigarette, and alcohol were identified as risk factors for malignant transformation of OSF in the Hunan province, Mainland China. Synergistic effects between BQ chewing and cigarette or alcohol consumption were revealed.