Spontaneous low frequency oscillations of cerebral hemodynamics and metabolism in human adults
Spontaneous low frequency oscillations of cerebral hemodynamics and metabolism in human adults
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DOI：
10.1006/nimg.2000.0657
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发表时间：
2000-12-01
期刊：
影响因子：
5.7
通讯作者：
Villringer, A
中科院分区：
文献类型：
--
作者：
Obrig, H;Neufang, M;Villringer, A
我们研究了成人视觉皮层中大脑氧合的缓慢自发振荡。其基本原理是（1）通过近红外光谱（NIRS）证明其可检测性;（2）分析不同MRS参数（氧合和脱氧血红蛋白和细胞色素氧化酶; oxy-Hb/deoxy-Hb/Cyt-ox）之间的光谱功率以及相位关系。（3）研究了功能性刺激和高碳酸血症对功率和相移的影响。结果表明，与文献一致，低频振荡（LFO）中心约为0.1 s（-1），甚至更慢的振荡，约0.04 s（-1）（甚低频，VLFO）可以区分。它们各自的功率在oxy-Hb、deoxy-Hb和Cyt ox之间不同。任一频率（LFO和VLFO）的幅度改变的功能刺激的皮质区检查。我们还发现血管参数（oxy-Hb，tot-Hb）和代谢参数（Cyt-ox）之间的相移的变化引起的刺激。研究表明，高碳酸血症会减弱氧合血红蛋白和脱氧血红蛋白的LFO。结论：（1）MRS可重复检测成人自发性血管性和代谢性LFO和VLFO。(2)它们的光谱特性和它们对高碳酸血症的响应与暴露的皮质中描述的那些一致（综述参见（Hudetz等人，1998））并与经颅多普勒超声检查（TCD）的结果相对应（Diehl等人，1995）和fMRI（Biswal等人，1997年）。(3)在LFO MRS参数之间的幅度和相位关系可以允许在成人大脑中的自动调节机制的局部非侵入性评估。(C)北京大学出版社.
We investigated slow spontaneous oscillations in cerebral oxygenation in the human adult's visual cortex. The rationale was (1) to demonstrate their detectability by near infrared spectroscopy (NIRS); (2) to analyze the spectral power of as well as the phase relationship between the different MRS parameters (oxygenated and deoxygenated hemoglobin and cytochrome-oxidase; oxy-Hb/deoxy-Hb/Cyt-ox). Also (3) influences of functional stimulation and hypercapnia on power and phase shifts were investigated. The results show that-in line with the literature-low frequency oscillations (LFO) centred around 0.1 s(-1) and even slower oscillations at; about 0.04 s(-1) (very low frequency, VLFO) can be distinguished. Their respective power differs between oxy-Hb, deoxy-Hb, and Cyt ox. Either frequency (LFO and VLFO) is altered in magnitude by functional stimulation of the cortical area examined. Also we find a change of the phase shift between the vascular parameters (oxy-Hb, tot-Hb) and the metabolic parameter (Cyt-ox) evoked by the stimulation. It is shown that hypercapnia attenuates the LFO in oxy-Hb and deoxy-Hb. Conclusions: (1) spontaneous vascular and metabolic LFO and VLFO calm be reproducibly detected by MRS in the human adult. (2) Their spectral characteristics and their response to hypercapnia are in line with those described in exposed cortex (for review see (Hudetz ef al., 1998)) and correspond to findings with transcranial doppler sonography (TCD) (Diehl ct al., 1995) and fMRI (Biswal et al., 1997). (3) The magnitude of and phase relation between MRS-parameters at the LFO may allow for a local noninvasive assessment of autoregulatory mechanisms in the adult brain. (C) 2000 Academic Press.