Short‐chain organic acidemia and Reye's syndrome
Short‐chain organic acidemia and Reye's syndrome
复制标题
短链有机酸血症和雷氏综合征
作者：
D. Trauner;W. Nyhan;L. Sweetman
对7例雷氏综合征患者进行了治疗前的短链脂肪酸测定。所有患者的丙酸、丁酸和异丁酸浓度均升高。3名患者的异戊酸酯浓度较高。鉴于实验动物给予某些短链脂肪酸可导致昏迷、脑电改变和内脏脂肪蓄积，本研究观察到的短链脂肪酸浓度升高提示这些脂肪酸可能在Reye综合征的临床表现中起作用。
Short-chain fatty acids were determined prior to therapy in seven patients with Reye's syndrome. Elevated concentrations of propionate, butyrate, and isobutyrate were found in all patients. Isovalerate concentrations were high in three patients. In view of the fact that the administration of certain short-chain fatty acids to experimental animals results in coma, electroen-cephalographic changes, and fatty accumulation in the viscera, the elevations of short-chain fatty acid concentrations observed in the present study suggest that these fatty acids may play a role in the clinical manifestations of Reye's syndrome.