The in Vivo Antioxidant Effects of (-)-Epigallocatechin-3-Gallate Consumption in Healthy Postmenopausal Women Measured by Urinary Excretion of Secondary Lipid Peroxidation Products.
The in Vivo Antioxidant Effects of (-)-Epigallocatechin-3-Gallate Consumption in Healthy Postmenopausal Women Measured by Urinary Excretion of Secondary Lipid Peroxidation Products.
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DOI：
10.4236/fns.2019.101002
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发表时间：
2019-01
期刊：
影响因子：
--
通讯作者：
Csallany AS
中科院分区：
文献类型：
--
作者：
Fiecke C;Kurzer M;Chen C;Csallany AS
本研究旨在探讨表没食子儿茶素(EGCG)对健康绝经后妇女体内氧化应激指标--体内脂质过氧化水平的降低是否有积极作用。40名参与者被随机分配到饮用绿茶儿茶素提取物(843.0±44.0mgEGCG/d)或安慰剂胶囊12个月后，测定了尿中次级脂质过氧化产物的排泄，这是体内脂质过氧化的衡量标准。在为期12个月的干预期开始和结束时，用高效液相色谱(HPLC)分析尿样中个别的极性和非极性亲脂醛和相关的羰基化合物。结果显示，服用EGCG后，两种非极性醛--壬醛和十一醛都降低了48%(p<；0.005)。这些结果表明，长期摄入EGCG后，体内存在适度的抗氧化活性，这可能会略微限制与脂质过氧化和慢性病的发生和发展相关的氧化损伤。
The present study was carried out to determine whether the consumption of epigallocatechin (EGCG), the major bioactive green tea catechin, exerts a positive effect on lowering in vivo lipid peroxidation, a measure of oxidative stress, in healthy postmenopausal women. Urinary excretion of secondary lipid peroxidation products, a measure of in vivo lipid peroxidation, was determined in 40 participants randomly assigned to consume a green tea catechin extract (843.0 ± 44.0 mg EGCG/d) or placebo capsules for 12 months. Urine samples were analyzed for individual polar and nonpolar lipophilic aldehydes and related carbonyl compounds by high-performance liquid chromatography (HPLC) at the beginning and at the end of the 12-month intervention period. Results show that two nonpolar aldehydes, nonanal and decatrienal, were both 48% lower (p < 0.005) following consumption of EGCG. These results indicate that a modest degree of in vivo antioxidant activity exists with long-term EGCG consumption, which could slightly limit oxidative damage associated with lipid peroxidation and the onset and progression of chronic diseases.