Mycobacterium avium Subspecies paratuberculosis: Human Exposure through Environmental and Domestic Aerosols.
Mycobacterium avium Subspecies paratuberculosis: Human Exposure through Environmental and Domestic Aerosols.
复制标题
DOI：
10.3390/pathogens3030577
复制
发表时间：
2014-07-16
期刊：
影响因子：
--
通讯作者：
Pickup R
中科院分区：
文献类型：
--
作者：
Rhodes G;Richardson H;Hermon-Taylor J;Weightman A;Higham A;Pickup R
鸟分枝杆菌副结核亚种（MAP）引起动物的约翰氏病，并与人类的克罗恩病（CD）显著相关。我们之前的研究表明Map存在于英国。由于牲畜慢性感染造成的土地沉积和降雨造成的径流，CD的流行病学在卡迪夫显示出显着的关联与塔夫河，其中地图可以定期检测。我们以前曾假设，来自河流的气溶胶可能会影响CD的流行病学。在这项初步研究中，我们检测地图的定量PCR在五个气溶胶样品收集以上的塔夫河。此外，我们还检查了来自英国不同地区的家用淋浴器。并在30个独立样本中的3个中检测到Map。在检测河流气溶胶和家庭淋浴中的MAP时，这是第一项提供证据证明气溶胶是MAP暴露于人类的途径，并可能在CD的流行病学中发挥作用的研究。
Mycobacterium avium subspecies paratuberculosis (Map) causes Johne’s disease in animals and is significantly associated with Crohn’s disease (CD) in humans. Our previous studies have shown Map to be present in U.K. rivers due to land deposition from chronic livestock infection and runoff driven by rainfall. The epidemiology of CD in Cardiff showed a significant association with the River Taff, in which Map can be detected on a regular basis. We have previously hypothesized that aerosols from the river might influence the epidemiology of CD. In this preliminary study, we detected Map by quantitative PCR in one of five aerosol samples collected above the River Taff. In addition, we examined domestic showers from different regions in the U.K. and detected Map in three out of 30 independent samples. In detecting Map in river aerosols and those from domestic showers, this is the first study to provide evidence that aerosols are an exposure route for Map to humans and may play a role in the epidemiology of CD.