The hippocampus constructs narrative memories across distant events.

The hippocampus constructs narrative memories across distant events.
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DOI:
10.1016/j.cub.2021.09.013
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发表时间:
2021-11-22
期刊:
影响因子:
9.2
通讯作者:
Ranganath, Charan
Ranganath, Charan
中科院分区:
生物学1区
文献类型:
--
作者:
Cohn-Sheehy, Brendan, I;Delarazan, Angelique, I;Reagh, Zachariah M.;Crivelli-Decker, Jordan E.;Kim, Kamin;Barnett, Alexander J.;Zacks, Jeffrey M.;Ranganath, Charan

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生活中的事件在时间上是分散的,但我们经常在一个完整的叙述中回忆起不同的事件。先前的研究表明,支持对过去事件的记忆的海马体可以支持记忆中重叠关联或独立事件的整合。然而,导致校园依赖性记忆整合的条件尚不清楚。我们使用功能性脑成像来测试形成更大叙事(叙事连贯性)的机会是否会驱动海马体记忆整合。在虚构故事的编码过程中,海马活动的模式,包括事件之间边界的活动,在形成一个连贯叙述的遥远事件之间更为相似,而从不相关的叙述中提取的重叠事件。一天后,海马优先支持详细回忆连贯的叙事事件,通过恢复海马活动模式编码。这些发现证明了海马体的一个关键功能:将事件整合到记忆的叙述结构中。
Life’s events are scattered throughout time, yet we often recall different events in the context of an integrated narrative. Prior research suggests that the hippocampus, which supports memory for past events, can support the integration of overlapping associations or separate events in memory. However, the conditions which lead to hippocampus-dependent memory integration are unclear. We used functional brain imaging to test whether the opportunity to form a larger narrative (narrative coherence) drives hippocampal memory integration. During encoding of fictional stories, patterns of hippocampal activity, including activity at boundaries between events, were more similar between distant events that formed one coherent narrative, compared with overlapping events taken from unrelated narratives. One day later, the hippocampus preferentially supported detailed recall of coherent narrative events, through reinstatement of hippocampal activity patterns from encoding. These findings demonstrate a key function of the hippocampus: the integration of events into a narrative structure for memory.
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