The Microbiota of Acute Apical Abscesses
The Microbiota of Acute Apical Abscesses
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DOI：
10.1177/0022034508328124
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发表时间：
2009-01-01
影响因子：
7.6
通讯作者：
Rocas, I. N.
中科院分区：
文献类型：
--
作者：
Siqueira, J. F., Jr.;Rocas, I. N.
随着口腔中细菌多样性的广度已被分子研究破译，几个新鉴定的物种/细菌类型已成为潜在的病原体。我们假设这些物种/真菌类型中的许多也可能与牙髓病的病因学有关。从42人的脓肿抽吸物进行了分析，通过反向捕获棋盘杂交试验的81种/ESTA类型的存在。计算了最常检测到的分类群之间的关联。最常见的类群是具核梭杆菌、微小单胞菌和牙髓卟啉单胞菌。其他常见的分类群包括Olsenella uli、链球菌、Eikenella corrodens、一些尚未培养的细菌类型（拟杆菌属克隆X 083和增效菌属克隆BA 121）和新命名的物种（巴氏普雷沃菌和小杆菌）。几个积极的细菌协会被披露。这些发现不仅加强了许多可栽培物种与该病的关联，而且还包括一些新命名的物种和未栽培的病原类型。
As the breadth of bacterial diversity in the oral cavity has been deciphered by molecular studies, several newly identified species/phylotypes have emerged as potential pathogens. We hypothesized that many of these species/phylotypes could also be involved with the etiology of endodontic abscesses. Abscess aspirates from 42 persons were analyzed for the presence of 81 species/phylotypes by means of a reverse-capture checkerboard hybridization assay. Associations between the most frequently detected taxa were calculated. The most prevalent taxa were Fusobacterium nucleatum, Parvimonas micra, and Porphyromonas endodontalis. Other frequently found taxa included Olsenella uli, streptococci, Eikenella corrodens, some as-yet-uncultivated phylotypes (Bacteroidetes clone X083 and Synergistes clone BA121), and newly named species (Prevotella baroniae and Dialister invisus). Several positive bacterial associations were disclosed. Findings not only strengthen the association of many cultivable species with abscesses, but also include some newly named species and uncultivated phylotypes in the set of candidate pathogens associated with this disease.