c-MET EXPRESSION AS AN INDICATOR OF SURVIVAL OUTCOME IN PATIENTS WITH ORAL TONGUE CARCINOMA
c-MET EXPRESSION AS AN INDICATOR OF SURVIVAL OUTCOME IN PATIENTS WITH ORAL TONGUE CARCINOMA
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DOI：
10.1002/hed.21383
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发表时间：
2010-12-01
影响因子：
2.9
通讯作者：
Choi, Eun Chang
中科院分区：
文献类型：
--
作者：
Kim, Chul-Ho;Koh, Yoon Woo;Choi, Eun Chang
背景。肝细胞生长因子（HGF）能促进多种肿瘤细胞的增殖、侵袭和血管生成。然而，根据HGF/c-Met的表达对口腔舌鳞癌（SCOOT）患者预后的影响尚未见报道。采用免疫组织化学方法对61例SCOOT患者的肿瘤进行HGF和c-Met的表达评估。在Western blot中，我们使用了3例scoot患者的新鲜正常组织和癌组织。HGF和c-Met免疫染色在SCOOT中的阳性率分别为57.3%和54.1%。c-Met染色与淋巴结转移（p = 0.005）、肿瘤分类（p = 0.004）、复发（p = 0.018）有显著相关性。c-Met阳性表达患者的生存受到显著影响（p = 0.003）。Western blot结果显示，HGF和c-Met在肿瘤组织中表达强烈。c-Met表达可能在SCOOT患者的进展和生存结局中起重要作用。(C) 2010 Wiley期刊公司中国生物医学工程学报（英文版），2010
Background. Hepatocyte growth factor (HGF) can promote proliferation, invasion, and angiogenesis in various tumor cells. However, the prognosis according to expression of HGF/c-Met has not been reported in patients with squamous cell carcinoma of the oral tongue (SCOOT).Methods. Tumors from 61 patients with SCOOT were evaluated for the expression of HGF and c-Met by immunohistochemistry. For Western blot, we used fresh normal and cancer tissues from 3 patients with SCOOT.Results. The positive rates of HGF and c-Met immunostaining in SCOOT were 57.3% and 54.1%, respectively. The c-Met staining was significantly correlated with lymph node metastasis (p = .005), tumor classification (p = .004), and recurrence (p = .018). Survival was significantly affected in patients with positive c-Met expression (p = .003). HGF and c-Met were strongly expressed in cancer tissues on Western blot.Conclusion. The c-Met expression may play an important role in the progression and the survival outcome of patients with SCOOT. (C) 2010 Wiley Periodicals, Inc. Head Neck 32: 1655-1664, 2010