Chronic infections and the risk of carotid atherosclerosis - Prospective results from a large population study
Chronic infections and the risk of carotid atherosclerosis - Prospective results from a large population study
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DOI：
10.1161/01.cir.103.8.1064
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发表时间：
2001-02-27
期刊：
影响因子：
37.8
通讯作者：
Willeit, J
中科院分区：
文献类型：
--
作者：
Kiechl, S;Egger, G;Willeit, J
Background-Chronic infections have been implicated in the pathogenesis of atherosclerosis, yet from an epidemiological perspective, this concept remains controversial.Methods and Results-The Bruneck Study is a prospective population-based survey on the pathogenesis of atherosclerosis, In 826 men and women 40 to 79 years old (1990 baseline), 5-year changes in carotid atherosclerosis were thoroughly assessed by high-resolution duplex scanning. The presence of chronic respiratory, urinary tract, dental, and other infections was ascertained by standard diagnostic criteria. Chronic infections amplified the risk of atherosclerosis development in the carotid arteries. The association was most pronounced in subjects free of carotid atherosclerosis at baseline (age-/sex-adjusted odds ratio [95% CI] for any chronic infection versus none, 4.08 [2.42 to 6.85]; P
