CELL-MEDIATED-IMMUNITY OF HEALTHY ADULT NOVA SCOTIANS IN VARIOUS AGE-GROUPS COMPARED WITH NURSING-HOME AND HOSPITALIZED SENIOR CITIZENS
CELL-MEDIATED-IMMUNITY OF HEALTHY ADULT NOVA SCOTIANS IN VARIOUS AGE-GROUPS COMPARED WITH NURSING-HOME AND HOSPITALIZED SENIOR CITIZENS
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DOI：
10.1016/0091-6749(88)90939-6
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发表时间：
1988-05-01
影响因子：
14.2
通讯作者：
DURANT, H
中科院分区：
文献类型：
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作者：
MARRIE, TJ;JOHNSON, S;DURANT, H
我们使用了Multitest CMI定义DTH反应(DTH)的149名健康成人新星Scotians(49岁男性和100名女性,年龄在25到82岁)和定义和比较健康的老年人的反应与79年(66 - 82岁)自给自足的老年人在养老院,25老年人在养老院但不是自给自足的,和15老年人急性护理医院住院。DTH的反应随着年龄的增长和养老院依赖性的增加而下降。因此，上述组中分别有1.5%、9.5%、17.9%、41.8%、60%和40%的受试者出现无能反应。对于健康受试者，年龄和性别是预测皮肤试验抗原阳性反应的重要因素。使用逻辑模型显示，对于男性受试者，积极反应的概率为Ln (p/1 - p) = 1.72 - 0.038（年龄），而对于女性受试者，它为Ln (p/1 - p) 0.59 - 0.0213（年龄）。当这个模型应用于老年人的反应时，那些住在家里的人的反应明显大于那些住在养老院的人。此外，那些在养老院生活时自给自足的人比那些不自给自足的人有更大的反应。
We used the Multitest CMI to define the delayed-type hypersensitivity response (DTH) of 149 healthy adult Nova Scotians (49 male and 100 female subjects, ranging in age from 25 to 82 years) and to define and compare the response of the healthy senior citizens (66 to 82 years old) with 79 self-sufficient senior citizens in a nursing home, 25 senior citizens in a nursing home but not self-sufficient, and 15 senior citizens hospitalized in an acute care hospital. The DTH response decreased with increasing age and with increasing dependency in a nursing home. Thus, 1.5%, 9.5%, 17.9%, 41.8%, 60%, and 40%, respectively, of the subjects in the groups listed above were anergic. For the healthy subjects, age and sex were significant factors in predicting a positive response to the skin test antigens. Use of a logistic model revealed that for male subjects, the probability of a positive response was Ln (p/1 - p) = 1.72 - 0.038 (age), whereas for female subjects, it was Ln (p/1 - p) 0.59 - 0.0213 (age). When this model was applied to the responses of senior citizens, those living at home had a significantly greater response than did those in nursing homes. Furthermore, those self-sufficient while they were living in a nursing home had a significantly greater response than those who were not self-sufficient.