neuromaps: structural and functional interpretation of brain maps.

neuromaps: structural and functional interpretation of brain maps.
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神经图:大脑图的结构和功能解释。

DOI:
10.1038/s41592-022-01625-w
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发表时间:
2022-11
期刊:
影响因子:
48
通讯作者:
Misic B
Misic B
中科院分区:
生物学1区
文献类型:
--
作者:
Markello RD;Hansen JY;Liu ZQ;Bazinet V;Shafiei G;Suárez LE;Blostein N;Seidlitz J;Baillet S;Satterthwaite TD;Chakravarty MM;Raznahan A;Misic B

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成像技术越来越多地用于生成大脑结构和功能的高分辨率参考图。将实验生成的地图与这些参考地图进行比较,有助于跨学科的科学发现。虽然最近的数据共享举措增加了脑图的可访问性,但数据通常在不同的坐标系统中共享,妨碍了系统和准确的比较。在这里,我们介绍神经地图,一个工具箱,用于访问,转换和分析结构和功能的大脑注释。我们实现了在四个标准坐标系之间生成高质量转换的功能。该工具箱包括精心策划的参考图和人类大脑的生物本体,如分子、微观结构、电生理、发育和功能本体。通过一套保持空间自相关的零模型,可以对地图之间的相似性进行稳健的定量评估。Neuromaps将开放获取数据与透明功能相结合,用于标准化和比较脑图,为人类大脑的全面结构和功能注释丰富分析提供系统的工作流程。Neuromaps是一个工具箱,用于访问、转换和比较人类神经成像数据。
Imaging technologies are increasingly used to generate high-resolution reference maps of brain structure and function. Comparing experimentally generated maps to these reference maps facilitates cross-disciplinary scientific discovery. Although recent data sharing initiatives increase the accessibility of brain maps, data are often shared in disparate coordinate systems, precluding systematic and accurate comparisons. Here we introduce neuromaps, a toolbox for accessing, transforming and analyzing structural and functional brain annotations. We implement functionalities for generating high-quality transformations between four standard coordinate systems. The toolbox includes curated reference maps and biological ontologies of the human brain, such as molecular, microstructural, electrophysiological, developmental and functional ontologies. Robust quantitative assessment of map-to-map similarity is enabled via a suite of spatial autocorrelation-preserving null models. neuromaps combines open-access data with transparent functionality for standardizing and comparing brain maps, providing a systematic workflow for comprehensive structural and functional annotation enrichment analysis of the human brain. neuromaps is a toolbox for accessing, transforming and comparing human neuroimaging data.
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