Neuroendocrinology: New hormone treatment for obesity caused by POMC-deficiency.
Neuroendocrinology: New hormone treatment for obesity caused by POMC-deficiency.
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神经内分泌学：针对 POMC 缺乏引起的肥胖的新激素治疗。
DOI：
10.1038/nrendo.2016.156
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Low,MalcolmJ
中科院分区：
文献类型：
--
作者：
Low,MalcolmJ
1998年，两名患有先天性肾上腺功能不全和早发性病态肥胖的儿童被发现在pomc中有致病的零突变。在一项新的研究中，黑色素皮质素-4受体激动剂setmelanotide的治疗首次为pomc缺乏症患者带来了正常生活的希望。
In 1998, two children with congenital adrenal insufficiency and early-onset morbid obesity were found to have causative null mutations inPOMC. In a new study, therapy with the melanocortin-4 receptor agonist setmelanotide has for the first time brought hope of a normal life to patients withPOMC-deficiency.