RECOMBINANT INTERFERON-GAMMA INDUCES HLA-DR EXPRESSION ON HUMAN CORNEAL EPITHELIAL AND ENDOTHELIAL-CELLS INVITRO - A PRELIMINARY-REPORT
RECOMBINANT INTERFERON-GAMMA INDUCES HLA-DR EXPRESSION ON HUMAN CORNEAL EPITHELIAL AND ENDOTHELIAL-CELLS INVITRO - A PRELIMINARY-REPORT
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DOI：
10.1136/bjo.73.8.587
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发表时间：
1989-08-01
影响因子：
4.1
通讯作者：
MISSOTTEN, L
中科院分区：
文献类型：
--
作者：
ELASRAR, AMA;VANDENOORD, JJ;MISSOTTEN, L
The effect of interferon-gamma on the expression in situ of major histocompatibility complex (MHC) products in human corneas was studied in vitro. Incubation for four days with 5 or 50 mg/l of Escherichia coli-derived recombinant human interferon-gamma resulted in the appearance de novo of MHC class II or HLA-DR antigens on variable numbers of corneal epithelial cells as well as on corneal endothelium, whereas it had no effect on the expression of MHC class I or HLA-ABC antigens. These results may help to explain the mechanism underlying the expression of HLA-DR antigens on corneal and limbal epithelium in various inflammatory eye diseases.
