Influence of sterilization upon a range of properties of experimental bone cements
Influence of sterilization upon a range of properties of experimental bone cements
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DOI：
10.1023/a:1018545519964
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发表时间：
1997-12-01
影响因子：
3.7
通讯作者：
Wahlig, H
中科院分区：
文献类型：
--
作者：
Harper, EJ;Braden, M;Wahlig, H
用于将假体固定到骨中的骨水泥必须在植入前灭菌。两种灭菌技术，γ和β辐射，进行了研究，检查分子量，静态和动态的机械特性和流变性能的影响。研究了由甲基丙烯酸甲酯（MMA）共聚物（单独粉末或粉末共混物）与MMA单体混合制备的许多实验水泥。发现在γ辐射和β辐射的情况下，所有粉末（包括MMA/苯乙烯共聚物）的分子量相对于辐射剂量降低。这种分子量的下降导致所有测试的水泥的拉伸强度、杨氏模量和应变失效下降。然而，动态测试突出了机械强度的劣化。在张力-张力测试后，在2 Hz的载荷控制下，用25 kGy的伽马辐照，骨水泥的疲劳寿命显示出显着下降。这一结果表明，在体内使用之前对实验性骨水泥进行此类测试至关重要。固化水泥的流变时间曲线也被发现是由25 kGy的γ辐射的影响，与灭菌后的复数粘度的减少。
Bone cement, used to fix prostheses into the bone, must be sterilized prior to implantation. Two sterilization techniques, gamma and beta radiation, were investigated, examining the influence upon molecular weight, static and dynamic mechanical characteristics and rheological properties. A number of experimental cements were studied prepared from methylmethacrylate (MMA) co-polymers, either single powders or powder blends, mixed with MMA monomer. It was found that with both gamma and beta radiation, there was a decrease in molecular weight of all powders, including a MMA/styrene co-polymer, in relation to the radiation dose. This fall in molecular weight resulted in a drop in tensile strength, Young's modulus and strain to failure of all cements tested. However, the deterioration in mechanical strength was highlighted by the dynamic testing. Fatigue lives of cements after testing in tension-tension, at 2 Hz under load control and irradiated with 25 kGy gamma radiation, displayed significant decreases. This result indicated the utmost importance of conducting such tests upon experimental bone cements prior to in vivo use. The rheological time profiles of curing cements were also found to be influenced by 25 kGy gamma radiation, with a reduction of complex viscosity after sterilization.