Ion channels in murine nuclei during early development and in fully differentiated adult cells.
Ion channels in murine nuclei during early development and in fully differentiated adult cells.
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早期发育期间小鼠细胞核和完全分化的成体细胞中的离子通道。
DOI：
10.1007/bf01870532
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Smith,EF
中科院分区：
文献类型：
--
作者：
Mazzanti,M;DeFelice,LJ;Smith,EF
核膜是细胞核与细胞质之间的选择性屏障。在细胞分裂的周期中，核被膜反复地分解和重新结合。据推测，每个周期都重建了核被膜的功能和结构完整性。在细胞分裂的重复循环之后，如在分化期间发生的，包膜的选择性和构型可能改变。我们比较了四种类型的小鼠细胞核的离子电导和核孔密度：胚泡在卵母细胞，原核在合子，核从两细胞卵裂球，体细胞核从肝脏。大电导离子通道存在于所有核膜中。肝细胞核具有比早期发育阶段更多的这些通道，并且它们也具有更高密度的核孔。在这篇文章中，我们假设之间的关联离子通道和核孔。
The nuclear envelope functions as a selective barrier between nucleus and cytoplasm. During cycles of cell division the nuclear envelope repeatedly disassembles and re-associates. Presumably, each cycle re-establishes the functional and structural integrity of the nuclear envelope. After repeated rounds of cell division, as occurs during differentiation, the selectivity and configuration of the envelope may change. We compare the ionic conductance and the nuclear pore density in four types of murine nuclei: germinal vesicles in oocytes, pronuclei in zygotes, nuclei from two-cell blastomeres, and somatic cell nuclei from the liver. A large-conductance ion channel is present in all nuclear envelopes. Liver cell nuclei have a greater number of these channels than those from earlier developmental stages, and they also have a higher density of nuclear pores. In this article we hypothesize an association between the ion channels and the nuclear pores.