Active immunotherapy and alternative therapeutic modalities for Alzheimer's disease.
Active immunotherapy and alternative therapeutic modalities for Alzheimer's disease.
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DOI：
10.1002/trc2.12090
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Carrillo MC
中科院分区：
文献类型：
--
作者：
Weninger S;Sperling B;Alexander R;Ivarsson M;Menzies FM;Powchik P;Weber CJ;Altar CA;Crystal RG;Haggarty SJ;Loring J;Bain LJ;Carrillo MC
随着对阿尔茨海默病（AD）进展的认识的提高，该领域已经认识到需要使管道多样化，拓宽治疗策略和方法以及递送机制。更好地了解AD/痴呆的最早生物学过程将有助于为药物靶点选择提供信息。目前，有一些项目正在探索这些替代途径。本次会议将允许该领域的专家（学术界，工业界，政府）提供观点和经验，可以帮助阐明今天的管道是什么样子，以及在开发跨AD阶段的新疗法方面有哪些途径。这里的重点是主动免疫疗法和替代治疗方式。本主题包括活性疫苗，反义寡聚体和基于细胞的治疗等，并强调了利用这些模式的新临床发展。
As knowledge of Alzheimer's disease (AD) progression improves, the field has recognized the need to diversify the pipeline, broaden strategies and approaches to therapies, as well as delivery mechanisms. A better understanding of the earliest biological processes of AD/dementia would help inform drug target selection. Currently there are a number of programs exploring these alternate avenues. This meeting will allow experts in the field (academia, industry, government) to provide perspectives and experiences that can help elucidate what the pipeline looks like today and what avenues hold promise in developing new therapies across the stages of AD. The focus here is on Active Immunotherapies and Alternative Therapeutic Modalities. This topic includes active vaccines, antisense oligomers, and cell‐based therapy among others, and highlights new clinical developments that utilize these modalities.
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DOI：
10.1523/jneurosci.4672-12.2013
发表时间：
2013-03-13
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Davtyan H;Ghochikyan A;Petrushina I;Hovakimyan A;Davtyan A;Poghosyan A;Marleau AM;Movsesyan N;Kiyatkin A;Rasool S;Larsen AK;Madsen PJ;Wegener KM;Ditlevsen DK;Cribbs DH;Pedersen LO;Agadjanyan MG
通讯作者：
Agadjanyan MG
影响因子：
64.8
作者：
Komor AC;Kim YB;Packer MS;Zuris JA;Liu DR
通讯作者：
Liu DR
影响因子：
120.7
作者：
Jansen, Willemijn J.;Ossenkoppele, Rik;Knol, Dirk L.;Tijms, Betty M.;Scheltens, Philip;Verhey, Frans R. J.;Visser, Pieter Jelle
通讯作者：
Visser, Pieter Jelle
影响因子：
64.8
作者：
Morgan, D;Diamond, DM;Arendash, GW
通讯作者：
Arendash, GW
影响因子：
168.9
作者：
Holmes, Clive;Boche, Delphine;Nicoll, James A. R.
通讯作者：
Nicoll, James A. R.