Cytochemical study of secretory process in transplantable insulinoma of syrian golden hamster.
Cytochemical study of secretory process in transplantable insulinoma of syrian golden hamster.
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叙利亚金仓鼠可移植胰岛素瘤分泌过程的细胞化学研究。
DOI：
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发表时间：
1975
影响因子：
11.1
通讯作者：
P. Novikoff
中科院分区：
文献类型：
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作者：
A. B. Novikoff;A. Yam;P. Novikoff
电子显微镜，包括磷酸酶细胞化学，表明分泌颗粒的胰岛素瘤产生胰岛素原和胰岛素包装内质网（ER），特别是由一个专门的区域，我们称之为GERL，因为这个区域的空间关系，高尔基体和其明显的作用，在生产溶酶体。这些颗粒不是来自高尔基体。初步证据表明，胰腺β细胞可能也是如此。
Electron microscopy, including phosphatase cytochemistry, indicates that the secretory granules of an insulinoma producing proinsulin and insulin are packaged by the endoplasmic reticulum (ER) and especially by a specialized region of ER which we call GERL because of the spatial relationship of this region to the Golgi apparatus and its apparent role in producing lysosomes. The granules are not derived from the Golgi apparatus. Preliminary evidence suggests this may be true also of pancreatic beta-cells.