OUTFLOW RESISTANCE OF ENUCLEATED HUMAN EYES AT 2 DIFFERENT PERFUSION PRESSURES AND DIFFERENT EXTENTS OF TRABECULOTOMY
OUTFLOW RESISTANCE OF ENUCLEATED HUMAN EYES AT 2 DIFFERENT PERFUSION PRESSURES AND DIFFERENT EXTENTS OF TRABECULOTOMY
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DOI：
10.3109/02713688909013902
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发表时间：
1989-12-01
影响因子：
2
通讯作者：
GRANT, WM
中科院分区：
文献类型：
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作者：
ROSENQUIST, R;EPSTEIN, D;GRANT, WM
在部分和完全（12小时）内部小梁切开术之前和之后，在7和25 mm Hg下测量摘除人眼的房水流出阻力。完全小梁切开术后，在25 mm Hg下消除了71%的阻力，而在7 mm Hg下仅消除了49%。与已发表的小梁网完整眼的研究结果（其中阻力随IOP增加而增加）相反（1），完全小梁切开术后，阻力随IOP增加每mmHg降低2%。限制于部分圆周的小梁切开术的实验表明，1小时小梁切开术产生的效果为12小时小梁切开术的41%（25 mm Hg）至60%（7 mm Hg）。结果表明，在正常IOP下，在流出系统的远端方面存在令人惊讶的高比例的房水流出阻力，并且该远端阻力随着IOP增加而下降。
Aqueous outflow resistance of enucleated human eyes was measured at 7 and 25 mm Hg before and after partial and complete (12 clock hours) internal trabeculotomy. Following complete trabeculotomy, 71% of the resistance was eliminated at 25 mm Hg while only 49% was eliminated at 7 mm Hg. In contrast to published findings in eyes with intact trabecular meshwork where the resistance increased with increasing IOP (1), following complete trabeculotomy, the resistance decreased 2% per mm Hg with increasing IOP. Experiments with trabeculotomy limited to part of the circumference showed that a one hour trabeculotomy produced 41% (25 mm Hg) to 60% (7 mm Hg) of the effect of a twelve hour trabeculotomy. The results indicate that a surprisingly high fraction of aqueous outflow resistance resides in the distal aspects of the outflow system at normal IOP, and that this distal resistance drops as IOP is increased.